Herrod Philip J J, Gharahdaghi Nima, Rudrappa Supreeth S, Phillips Hannah G, Ranat Reesha A, Hardy Edward J O, Rathmacher John A, Atherton Philip J, Phillips Bethan E
MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Nottingham, School of Medicine, Royal Derby Hospital Centre, Derby, UK.
Department of Surgery and Anaesthetics, Royal Derby Hospital, Derby, UK.
J Funct Foods. 2020 Oct;73:104163. doi: 10.1016/j.jff.2020.104163.
Insulin resistance (IR) is a key feature in the development of numerous metabolic diseases. The cornerstone for treatment for IR remains diet and exercise, however these have poor rates of adherence. Beta-hydroxy-beta-methylbutyrate (HMB) is a nutraceutical with contentious effects on IR in animal models. The aim of this study was to evaluate the impact of acute HMB on IR in humans during an oral glucose tolerance test (OGTT). Young and older male volunteers underwent two 75 g OGTT with or without 3 g HMB. In young men, HMB significantly reduced the insulin area-under-the-curve (AUC), with no difference in glucose AUC, resulting in a numerical increase in the Cederholm index of insulin sensitivity. In older men, HMB had no effect on insulin or glucose responses. In conclusion, acute HMB may improve IR following a glucose load in young men; however, this does not appear to be sustained into older age.
胰岛素抵抗（IR）是众多代谢性疾病发展过程中的一个关键特征。治疗IR的基石仍然是饮食和运动，然而这些方法的依从率很低。β-羟基-β-甲基丁酸酯（HMB）是一种营养保健品，在动物模型中对IR有争议性的影响。本研究的目的是评估在口服葡萄糖耐量试验（OGTT）期间急性给予HMB对人体IR的影响。年轻和年长男性志愿者分别进行了两次75克OGTT，一次给予3克HMB，另一次不给予。在年轻男性中，HMB显著降低了胰岛素曲线下面积（AUC），而葡萄糖AUC没有差异，导致胰岛素敏感性的Cederholm指数出现数值增加。在年长男性中，HMB对胰岛素或葡萄糖反应没有影响。总之，急性给予HMB可能会改善年轻男性葡萄糖负荷后的IR；然而，这种作用在年长男性中似乎无法持续。
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