• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

三氧化二砷对宫颈癌的作用及其机制。

Effect of arsenic trioxide on cervical cancer and its mechanisms.

作者信息

Zhang Liping, Zhou Yanan, Kong Jing, Zhang Li, Yuan Mengqin, Xian Shu, Wang Yanqing, Cheng Yanxiang, Yang Xiaofeng

机构信息

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi 710061, P.R. China.

Department of Obstetrics and Gynecology, Wuhan Children's Hospital and Wuhan Maternal and Child Healthcare Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430060, P.R. China.

出版信息

Exp Ther Med. 2020 Dec;20(6):169. doi: 10.3892/etm.2020.9299. Epub 2020 Oct 9.

DOI:10.3892/etm.2020.9299
PMID:33101463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7579781/
Abstract

Cervical cancer is one of the most common types of gynecological tumor, and thus identifying complementary or substitute treatment methods to treat cervical cancer is important. The present study aimed to evaluate the effect of arsenic trioxide (ATO), a traditional Chinese medicine, on cervical cancer cells and its underlying mechanism. MTT, colony formation and Transwell assays were performed to investigate the effects of different concentrations of ATO on cell proliferation and invasion, respectively. Western blotting and reverse transcription-quantitative PCR were applied to measure hypoxia-inducible factor-1α expression (HIF-1α) expression following ATO treatment. Finally, the effects of HIF-1α knockdown on cervical cancer cell proliferation, apoptosis and invasion were evaluated. The results demonstrated that ATO could inhibit cell proliferation and invasion. Moreover, ATO could induce reactive oxygen species production in a time- and dose-dependent manner. ATO could also promote the apoptosis of cervical cancer cells via HIF-1α. Therefore, the present study may provide a theoretical basis for identifying effective molecular targets for the prevention and treatment of cervical cancer.

摘要

宫颈癌是最常见的妇科肿瘤类型之一，因此确定治疗宫颈癌的补充或替代治疗方法很重要。本研究旨在评估中药三氧化二砷（ATO）对宫颈癌细胞的作用及其潜在机制。分别进行MTT、集落形成和Transwell实验，以研究不同浓度ATO对细胞增殖和侵袭的影响。采用蛋白质免疫印迹法和逆转录-定量PCR检测ATO处理后缺氧诱导因子-1α（HIF-1α）的表达。最后，评估敲低HIF-1α对宫颈癌细胞增殖、凋亡和侵袭的影响。结果表明，ATO可抑制细胞增殖和侵袭。此外，ATO能以时间和剂量依赖性方式诱导活性氧生成。ATO还可通过HIF-1α促进宫颈癌细胞凋亡。因此，本研究可能为确定宫颈癌预防和治疗的有效分子靶点提供理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa4f/7579781/d449e350e724/etm-20-06-09299-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa4f/7579781/c4dba0d04e26/etm-20-06-09299-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa4f/7579781/735a6ef805e5/etm-20-06-09299-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa4f/7579781/5f62c78f7215/etm-20-06-09299-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa4f/7579781/a06e4985b958/etm-20-06-09299-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa4f/7579781/08939c25e020/etm-20-06-09299-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa4f/7579781/d449e350e724/etm-20-06-09299-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa4f/7579781/c4dba0d04e26/etm-20-06-09299-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa4f/7579781/735a6ef805e5/etm-20-06-09299-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa4f/7579781/5f62c78f7215/etm-20-06-09299-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa4f/7579781/a06e4985b958/etm-20-06-09299-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa4f/7579781/08939c25e020/etm-20-06-09299-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa4f/7579781/d449e350e724/etm-20-06-09299-g05.jpg

相似文献

1
Effect of arsenic trioxide on cervical cancer and its mechanisms.三氧化二砷对宫颈癌的作用及其机制。
Exp Ther Med. 2020 Dec;20(6):169. doi: 10.3892/etm.2020.9299. Epub 2020 Oct 9.
2
[Influence of hypoxia inducible factor-1alpha on cervical cancer cell line HeLa in vitro].[缺氧诱导因子-1α对宫颈癌HeLa细胞系的体外影响]
Zhonghua Fu Chan Ke Za Zhi. 2007 Aug;42(8):551-4.
3
Arsenic trioxide and BIBR1532 synergistically inhibit breast cancer cell proliferation through attenuation of NF-κB signaling pathway.三氧化二砷和 BIBR1532 通过抑制 NF-κB 信号通路协同抑制乳腺癌细胞增殖。
Life Sci. 2020 Sep 15;257:118060. doi: 10.1016/j.lfs.2020.118060. Epub 2020 Jul 6.
4
Arsenic trioxide plus PX-478 achieves effective treatment in pancreatic ductal adenocarcinoma.三氧化二砷联合PX-478对胰腺导管腺癌有有效治疗作用。
Cancer Lett. 2016 Aug 10;378(2):87-96. doi: 10.1016/j.canlet.2016.05.016. Epub 2016 May 19.
5
TLR4 promotes the expression of HIF-1α by triggering reactive oxygen species in cervical cancer cells in vitro-implications for therapeutic intervention.TLR4 通过在体外触发宫颈癌细胞中的活性氧来促进 HIF-1α 的表达——这对治疗干预具有重要意义。
Mol Med Rep. 2018 Feb;17(2):2229-2238. doi: 10.3892/mmr.2017.8108. Epub 2017 Nov 20.
6
Arsenic trioxide inhibits CXCR4-mediated metastasis by interfering miR-520h/PP2A/NF-κB signaling in cervical cancer.三氧化二砷通过干扰宫颈癌中miR-520h/PP2A/NF-κB信号通路抑制CXCR4介导的转移。
Ann Surg Oncol. 2014 Dec;21 Suppl 4:S687-95. doi: 10.1245/s10434-014-3812-5. Epub 2014 Jul 22.
7
Arsenic trioxide suppresses cell growth and migration via inhibition of miR-27a in breast cancer cells.三氧化二砷通过抑制乳腺癌细胞中的miR-27a来抑制细胞生长和迁移。
Biochem Biophys Res Commun. 2016 Jan 1;469(1):55-61. doi: 10.1016/j.bbrc.2015.11.071. Epub 2015 Nov 22.
8
Hypoxia inducible factor-1α-mediated activation of survivin in cervical cancer cells.缺氧诱导因子-1α介导的子宫颈癌细胞中生存素激活
J Obstet Gynaecol Res. 2013 Feb;39(2):555-63. doi: 10.1111/j.1447-0756.2012.01995.x. Epub 2012 Aug 26.
9
Antitumor activity of arsenic trioxide on retinoblastoma: cell differentiation and apoptosis depending on arsenic trioxide concentration.三氧化二砷对视网膜母细胞瘤的抗肿瘤活性：细胞分化和凋亡取决于三氧化二砷的浓度。
Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1819-23. doi: 10.1167/iovs.08-2623. Epub 2008 Dec 5.
10
Differential anticancer activities of arsenic trioxide on head and neck cancer cells with different human papillomavirus status.三氧化二砷对不同人乳头瘤病毒状态的头颈部癌细胞的抗癌活性差异。
Life Sci. 2018 Nov 1;212:182-193. doi: 10.1016/j.lfs.2018.09.033. Epub 2018 Sep 20.

引用本文的文献

1
Heavy metal carcinogenicity: a scoping review of observational & experimental evidence.重金属致癌性：观察性与实验性证据的范围综述
Front Oncol. 2025 Aug 11;15:1569816. doi: 10.3389/fonc.2025.1569816. eCollection 2025.
2
Arsenic trioxide: applications, mechanisms of action, toxicity and rescue strategies to date.三氧化二砷：应用、作用机制、毒性及迄今的抢救策略。
Arch Pharm Res. 2024 Mar;47(3):249-271. doi: 10.1007/s12272-023-01481-y. Epub 2023 Dec 26.
3
Antitumor effects of Chinese herbal medicine compounds and their nano-formulations on regulating the immune system microenvironment.

本文引用的文献

1
miR‑96 exerts an oncogenic role in the progression of cervical cancer by targeting CAV‑1.miR-96 通过靶向 CAV-1 在宫颈癌的进展中发挥致癌作用。
Mol Med Rep. 2020 Jul;22(1):543-550. doi: 10.3892/mmr.2020.11101. Epub 2020 Apr 30.
2
Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis.2018 年宫颈癌发病率和死亡率的估计：全球分析。
Lancet Glob Health. 2020 Feb;8(2):e191-e203. doi: 10.1016/S2214-109X(19)30482-6. Epub 2019 Dec 4.
3
Lycopene alleviates HO-induced oxidative stress, inflammation and apoptosis in bovine mammary epithelial cells via the NFE2L2 signaling pathway.
中草药化合物及其纳米制剂对调节免疫系统微环境的抗肿瘤作用。
Front Oncol. 2022 Sep 23;12:949332. doi: 10.3389/fonc.2022.949332. eCollection 2022.
4
Albumin-Embellished Arsenic Trioxide-Loaded Polymeric Nanoparticles Enhance Tumor Accumulation and Anticancer Efficacy via Transcytosis for Hepatocellular Carcinoma Therapy.载三氧化二砷白蛋白修饰的聚合物纳米粒通过转胞吞作用增强肝癌的肿瘤蓄积和抗肿瘤疗效。
AAPS PharmSciTech. 2022 Apr 11;23(4):111. doi: 10.1208/s12249-022-02254-4.
5
Mineral medicine: from traditional drugs to multifunctional delivery systems.矿物药物：从传统药物到多功能给药系统
Chin Med. 2022 Feb 10;17(1):21. doi: 10.1186/s13020-022-00577-9.
6
Exploring the Mechanisms of Arsenic Trioxide () in Hepatocellular Carcinoma Based on Network Pharmacology.基于网络药理学探索三氧化二砷治疗肝细胞癌的机制
Evid Based Complement Alternat Med. 2021 Nov 29;2021:5773802. doi: 10.1155/2021/5773802. eCollection 2021.
番茄红素通过 NFE2L2 信号通路缓解 HO 诱导的奶牛乳腺上皮细胞氧化应激、炎症和细胞凋亡。
Food Funct. 2019 Oct 16;10(10):6276-6285. doi: 10.1039/c9fo01922g.
4
Mitochondrial electron transport chain, ROS generation and uncoupling (Review).线粒体电子传递链、ROS 生成和解偶联（综述）。
Int J Mol Med. 2019 Jul;44(1):3-15. doi: 10.3892/ijmm.2019.4188. Epub 2019 May 8.
5
Estimated Number of Cases of High-Grade Cervical Lesions Diagnosed Among Women - United States, 2008 and 2016.2008 年和 2016 年美国女性中诊断出的高级别宫颈病变估计病例数。
MMWR Morb Mortal Wkly Rep. 2019 Apr 19;68(15):337-343. doi: 10.15585/mmwr.mm6815a1.
6
[Research progress in mechanism of traditional Chinese medicine active ingredients against cervical cancer].[中药活性成分抗宫颈癌作用机制的研究进展]
Zhongguo Zhong Yao Za Zhi. 2019 Feb;44(4):675-684. doi: 10.19540/j.cnki.cjcmm.20181220.002.
7
Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.砷靶向 Pin1，并与维甲酸协同抑制致癌途径和肿瘤起始细胞。
Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
8
Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide.信号转导子和转录激活子 3（STAT3）和 Bcl-2 的激活以及活性氧（ROS）的减少可促进乳腺癌的放射抵抗，并通过氯硝柳胺克服放射抵抗。
Oncogene. 2018 Sep;37(39):5292-5304. doi: 10.1038/s41388-018-0340-y. Epub 2018 May 31.
9
Development of a clinical protocol for detection of cervical cancer precursor lesions.宫颈癌前病变检测临床方案的制定。
Rev Lat Am Enfermagem. 2018;26:e2999. doi: 10.1590/1518-8345.2340.2999. Epub 2018 May 17.
10
Arsenic trioxide induces apoptosis and inhibits the growth of human liver cancer cells.三氧化二砷诱导肝癌细胞凋亡并抑制其生长。
Life Sci. 2018 Jul 15;205:9-17. doi: 10.1016/j.lfs.2018.05.006. Epub 2018 May 5.