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骨密度测定在银屑病关节炎骨质疏松和骨质减少中的作用

Role of osteodensitometry in osteoporosis and osteopenia in psoriatic arthritis.

作者信息

Brihan Ilarie, Hălmăjan Angelica, Boda Daniel, Ianoși Simona Laura, Fekete Gyula László, Zdrîncă Mihaela

机构信息

Dermatology Department, Dermatology Clinic, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.

Psychology Department, Faculty of Social-Humanistic Sciences, University of Oradea, 410073 Oradea, Romania.

出版信息

Exp Ther Med. 2020 Dec;20(6):188. doi: 10.3892/etm.2020.9318. Epub 2020 Oct 13.

Abstract

Dual-energy X-ray Absorptiometry (DEXA) determines the mineral contents for the spine, the proximal femur and the entire body. A group of 36 patients with psoriatic arthritis were chosen, with different types of arthropathy, from the total 82 patients with psoriatic arthritis in the study group, for which bone mineral density (BMD) was measured, using the DEXA technique. The chosen study group comprised 12 men, 12 premenopausal women and 12 menopausal women, with psoriatic joint damage and a group of 36 healthy individuals, divided based on the same criteria: Men, premenopausal and menopausal women. This study did not emphasize an association between the patient type and the presented bone demineralization type (χ =4.473, P=0.107) in men. In premenopausal women, there was a significant association between the patient type and the presented bone demineralization type (χ =8.778, P=0.012), as the female patients with psoriatic arthritis presented total and partial demineralization to a larger degree, compared with healthy individuals. In menopausal women, this study did not highlight an association between the patient type and the presented bone demineralization type (χ =4.523, P=0.104). Bone demineralization was significant in all three patient groups, both total and partial, in patients with psoriatic arthritis compared with healthy patients. Bone demineralization manifested as osteopenia, with T-scores ranging from -2.5 to -1, and not as osteoporosis. Determining B MD by DEXA technique revealed osteopenia to a higher degree within the group of patients with psoriatic arthritis compared with the healthy patients, as well as the absence of osteoporosis in psoriatic arthritis.

摘要

双能X线吸收法(DEXA)可测定脊柱、股骨近端和全身的矿物质含量。从研究组82例银屑病关节炎患者中选取36例患有不同类型关节病的患者,采用DEXA技术测量其骨密度(BMD)。所选研究组包括12名男性、12名绝经前女性和12名绝经后女性,均患有银屑病关节损伤,以及一组36名健康个体,根据相同标准划分:男性、绝经前女性和绝经后女性。本研究未强调男性患者类型与所呈现的骨质脱矿类型之间的关联(χ=4.473,P=0.107)。在绝经前女性中,患者类型与所呈现的骨质脱矿类型之间存在显著关联(χ=8.778,P=0.012),因为与健康个体相比,银屑病关节炎女性患者出现完全和部分脱矿的程度更大。在绝经后女性中,本研究未突出患者类型与所呈现的骨质脱矿类型之间的关联(χ=4.523,P=0.104)。与健康患者相比,银屑病关节炎患者的所有三个患者组中,完全和部分骨质脱矿均很显著。骨质脱矿表现为骨质减少,T值范围为-2.5至-1,而非骨质疏松症。通过DEXA技术测定BMD显示,与健康患者相比,银屑病关节炎患者组中骨质减少程度更高,且银屑病关节炎患者中不存在骨质疏松症。

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