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电针与镇痛药对顺铂化疗后IIIB期宫颈癌患者的疗效比较

Electroacupuncture Versus Analgesics for Patients with Stage IIIB Cervical Cancer Post Cisplatin Chemotherapy.

作者信息

Saraswati Wita, Rosyiadi Mochammad Rizalul, Imandiri Ario

机构信息

Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

Department of Traditional Healer, Faculty of Vocations, Universitas Airlangga, Surabaya, Indonesia.

出版信息

Med Acupunct. 2020 Oct 1;32(5):293-299. doi: 10.1089/acu.2020.1425. Epub 2020 Oct 19.

Abstract

The prevalence of pain at advanced cervical cancer stages is increasing. Existing World Health Organization recommendations for management comprises a 3-step ladder of analgesic therapy but this still cannot address this pain optimally. An alternative therapy used to reduce pain, acupuncture, is almost without side-effects, is safe, and is easy to implement. This study compared electroacupuncture (EA) versus paracetamol 500 mg +10-mg codeine therapy for patients with stage-IIIB cervical cancer post cisplatin chemotherapy. Participants were divided into 2 groups (treatment and control groups). A quasiexperimental study was conducted using a nonequivalent control group pretest-post-test design. Participants in the treatment group were given EA for 30 minutes 10 times over 3 weeks, while participants in the control group were given paracetamol 3 × 500 mg and codeine 3 × 10 mg orally every day for 3 weeks. Statistical analysis used paired -tests, a Wilcoxon test, an independent -test, or a Mann-Whitney- test with  < 0.05. Pretest and post-test pain-scale levels were 5.39 ± 0.62 and 4.57 ± 0.88, respectively ( < 0.001). Average endorphin-β levels at pretest and post-test were 571.80 ± 281.13 and 491.14 ± 272.14, respectively ( = 0.818). Median values of quality of life at pretest and post-test were 681.75 (range: 503.80-915.20) and 635.25 (range: 538.20-781.20;  = 0.383), respectively. Pain-control therapy using drugs or EA produces similar results. However, EA, subjectively, produces improved pain-scale results better than pharmaceuticals.

摘要

晚期宫颈癌阶段疼痛的发生率正在上升。世界卫生组织现有的管理建议包括一个三步阶梯镇痛疗法,但这仍无法最佳地解决这种疼痛。一种用于减轻疼痛的替代疗法——针灸,几乎没有副作用,安全且易于实施。本研究比较了电针(EA)与对乙酰氨基酚500毫克+10毫克可待因疗法对IIIB期宫颈癌顺铂化疗后的患者的效果。参与者被分为两组(治疗组和对照组)。采用非等效对照组前测-后测设计进行了一项准实验研究。治疗组的参与者在3周内接受10次每次30分钟的电针治疗,而对照组的参与者在3周内每天口服3次每次500毫克的对乙酰氨基酚和3次每次10毫克的可待因。统计分析使用配对t检验、威尔科克森检验、独立t检验或曼-惠特尼U检验,P<0.05。前测和后测的疼痛量表水平分别为5.39±0.62和4.57±0.88(P<0.001)。前测和后测的平均内啡肽-β水平分别为571.80±281.13和491.14±272.14(P=0.818)。前测和后测的生活质量中位数分别为681.75(范围:503.80-915.20)和635.25(范围:538.20-781.20;P=0.383)。使用药物或电针的疼痛控制疗法产生相似的结果。然而,主观上,电针产生的疼痛量表结果比药物更好。

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