• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Bioethical Implications in Vaccine Development, a COVID-19 Challenge.疫苗研发中的生物伦理问题:新冠疫情带来的挑战
Cureus. 2020 Sep 18;12(9):e10530. doi: 10.7759/cureus.10530.
2
Current Clinical Trials Protocols and the Global Effort for Immunization against SARS-CoV-2.当前的临床试验方案与全球新冠病毒免疫接种行动
Vaccines (Basel). 2020 Aug 25;8(3):474. doi: 10.3390/vaccines8030474.
3
Current updates and research on plant-based vaccines for coronavirus disease 2019.2019冠状病毒病植物源疫苗的最新进展与研究
Clin Exp Vaccine Res. 2021 Jan;10(1):13-23. doi: 10.7774/cevr.2021.10.1.13. Epub 2021 Jan 31.
4
COVID-19 Outbreak in Malaysia.马来西亚的新冠疫情爆发。
Osong Public Health Res Perspect. 2020 Jun;11(3):93-100. doi: 10.24171/j.phrp.2020.11.3.08.
5
6
COVID-19 Vaccine Acceptance: We Need to Start Now.新冠疫苗接种意愿:我们现在就得行动起来。
Open Forum Infect Dis. 2021 Jan 4;8(2):ofaa658. doi: 10.1093/ofid/ofaa658. eCollection 2021 Feb.
7
Research Updates for Influenza Virus and Vaccine Development.流感病毒与疫苗研发的研究进展
Vaccines (Basel). 2021 Apr 14;9(4):383. doi: 10.3390/vaccines9040383.
8
Self-inflicted wounds.自伤。
Science. 2021 Nov 12;374(6569):793. doi: 10.1126/science.abn1244. Epub 2021 Nov 11.
9
Bioethics in the COVID-19 Pandemic Research: Challenges and Strategies.新冠疫情研究中的生物伦理学:挑战与策略
Rev Invest Clin. 2020 May 7;72(5):265-270. doi: 10.24875/RIC.20000258.
10
Psychological Implications of Mandatory Testing for Severe Acute Respiratory Syndrome Coronavirus 2 During the Global COVID-19 Pandemic.全球新冠疫情期间2019冠状病毒病强制检测的心理影响
J Neurol Res. 2020 Dec;10(6):207-208. doi: 10.14740/jnr634. Epub 2020 Dec 9.

本文引用的文献

1
The Covid-19 Vaccine-Development Multiverse.新冠疫苗研发多元世界。
N Engl J Med. 2020 Nov 12;383(20):1986-1988. doi: 10.1056/NEJMe2025111. Epub 2020 Jul 14.
2
Accelerating Development of SARS-CoV-2 Vaccines - The Role for Controlled Human Infection Models.加速严重急性呼吸综合征冠状病毒2(SARS-CoV-2)疫苗的研发——人体感染控制模型的作用
N Engl J Med. 2020 Sep 3;383(10):e63. doi: 10.1056/NEJMp2020076. Epub 2020 Jul 1.
3
The impact of COVID-19 and strategies for mitigation and suppression in low- and middle-income countries.新冠疫情的影响以及中低收入国家的缓解和抑制策略。
Science. 2020 Jul 24;369(6502):413-422. doi: 10.1126/science.abc0035. Epub 2020 Jun 12.
4
Ethics of controlled human infection to address COVID-19.用于应对新冠疫情的人体感染对照试验伦理问题。
Science. 2020 May 22;368(6493):832-834. doi: 10.1126/science.abc1076. Epub 2020 May 7.
5
Extraordinary diseases require extraordinary solutions.特殊的疾病需要特殊的解决方案。
Vaccine. 2020 May 19;38(24):3987-3988. doi: 10.1016/j.vaccine.2020.04.039. Epub 2020 Apr 20.
6
Human Challenge Studies to Accelerate Coronavirus Vaccine Licensure.人类挑战研究加速冠状病毒疫苗许可。
J Infect Dis. 2020 May 11;221(11):1752-1756. doi: 10.1093/infdis/jiaa152.
7
Covid-19 - Navigating the Uncharted.新冠疫情——探索未知领域。
N Engl J Med. 2020 Mar 26;382(13):1268-1269. doi: 10.1056/NEJMe2002387. Epub 2020 Feb 28.
8
Defining the Epidemiology of Covid-19 - Studies Needed.定义新冠病毒病的流行病学——所需的研究。
N Engl J Med. 2020 Mar 26;382(13):1194-1196. doi: 10.1056/NEJMp2002125. Epub 2020 Feb 19.
9
Evolving status of the 2019 novel coronavirus infection: Proposal of conventional serologic assays for disease diagnosis and infection monitoring.2019新型冠状病毒感染的演变情况:疾病诊断和感染监测常规血清学检测方法的建议
J Med Virol. 2020 May;92(5):464-467. doi: 10.1002/jmv.25702. Epub 2020 Feb 17.
10
Conducting clinical trials in outbreak settings: Points to consider.在疫情爆发环境中开展临床试验:需考虑的要点。
Clin Trials. 2016 Feb;13(1):92-5. doi: 10.1177/1740774515618198. Epub 2016 Jan 14.

疫苗研发中的生物伦理问题:新冠疫情带来的挑战

Bioethical Implications in Vaccine Development, a COVID-19 Challenge.

作者信息

Ospina Henao Sebastián, Marín Mora Alejandro, Chan Solano Fanny, Ávila-Aguero María L

机构信息

Instituto de Investigación en Ciencias Médicas, Universidad de Ciencias Médicas, San José, CRI.

Centro de Estudios en Bioderecho, Ética y Salud, Universidad de Murcia, Murcia, ESP.

出版信息

Cureus. 2020 Sep 18;12(9):e10530. doi: 10.7759/cureus.10530.

DOI:10.7759/cureus.10530
PMID:33101792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7575135/
Abstract

Introduction In the last 18 years, on three occasions, coronavirus has represented a challenge for global health. Between 2002 and 2003 with Severe Acute Respiratory Syndrome, in 2012 with Middle East Respiratory Syndrome, and since the end of 2019 with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease 2019 (COVID-19) pandemic, which has challenged health care models and the way of doing research, placing bioethics at the center of discussion.  Methods On August 19, 2020, a webinar organized by the Research Institute of Medical Science (IICIMED, for its acronym in Spanish), entitled 'Bioethical Implications in Vaccine Development, a COVID-19 Challenge' took place. Three experts spoke about the importance of bioethics in the race to develop a COVID-19 vaccine, the risk involved in shortening the terms of the clinical trial phases, and how the associated risks can be minimized, in order to expedite research results.  Conclusion With the novel SARS-CoV-2 coronavirus, critical challenges have been posed not only for public health but for research and the scientific community. A safe and effective vaccine is urgently needed to prevent COVID-19 transmission, complications, and deaths; the adherence to ethical principles required by clinical research is mandatory and closer supervision is also essential.

摘要

引言 在过去18年里,冠状病毒曾三次给全球健康带来挑战。2002年至2003年出现严重急性呼吸综合征,2012年出现中东呼吸综合征,自2019年底以来,严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引发了2019冠状病毒病(COVID-19)大流行,这对医疗保健模式和研究方式构成了挑战,使生物伦理学成为讨论的核心。

方法 2020年8月19日,医学科学研究所(IICIMED,西班牙语首字母缩写)组织了一次网络研讨会,主题为“疫苗研发中的生物伦理问题,COVID-19的挑战”。三位专家谈到了生物伦理学在COVID-19疫苗研发竞赛中的重要性、缩短临床试验阶段期限所涉及的风险,以及如何将相关风险降至最低以加快研究成果。

结论 新型SARS-CoV-2冠状病毒不仅给公共卫生带来了严峻挑战,也给研究和科学界带来了挑战。迫切需要一种安全有效的疫苗来预防COVID-19的传播、并发症和死亡;必须遵守临床研究所需的伦理原则,加强监督也至关重要。