Liu HaiLing, Yao ZhiNa, Zhang Rougxiu, Wu SheLing, Lv ShangGe, Yan Lei
Department of Reproductive Medicine, People's Hospital of Rizhao, Jinan, China.
Department of Obstetrics and Gynecology, School of Medicine, Jinan, China.
Gynecol Minim Invasive Ther. 2020 Aug 1;9(3):118-122. doi: 10.4103/GMIT.GMIT_27_19. eCollection 2020 Jul-Sep.
The objective of the study was to evaluate the effects of recurrent hydrosalpinx after proximal tubal ligation and distal salpingostomy on the outcomes of fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment.
Seven hundred and twenty-six patients with hydrosalpinx undergoing laparoscopic surgery before IVF were enrolled in the study. Five hundred and sixty-two patients treated with proximal tubal ligation and distal salpingostomy were included in Group A. One hundred and sixty-four cases managed with salpingectomy were grouped into Group B. Group A were further divided into two subgroups. One hundred and forty-six patients in Group A1 had a recurrence of hydrosalpinx. Four hundred and sixteen patients in Group A2 had no repetition of hydrosalpinx. We compared the pregnancy outcomes of their subsequent fresh embryo transfer cycles among the three groups.
There were no significant differences among the three groups in terms of age, body mass index (23.56 ± 3.27 vs. 23.13 ± 3.42 vs. 23.63 ± 3.73, = 0.195), basal hormone level (7.03 ± 1.75 vs. 7.08 ± 2.26 vs. 7.44 ± 2.93, = 0.195), antral follicle count (12.25 ± 5.92 vs. 12.63 ± 5.71 vs. 11.70 ± 4.98, = 0.188), duration of gonadotropin (Gn) (11.19 ± 2.1 vs. 10.93 ± 1.84 vs. 10.79 ± 2.03, = 0.182), consumption of Gn (2136.73 ± 855.65 vs. 1997.15 ± 724.72 vs. 2069.05±765.12 , = 0.14), endometrial thickness (1.1 ± 0.27 vs. 1.1 ± 0.24 vs. 1.1 ± 0.17, = 0.352), base follicle-stimulating hormone (6.21 ± 3.43 vs. 6.52 ± 3.20 vs. 5.89 ± 3.10, = 0.1), number of embryos transferred (1.87 ± 0.36 vs. 1.83 ± 0.42 vs. 1.88 ± 0.37, = 0.224), and number of high-grade embryos (3.77 ± 2.42 vs. 4.01 ± 2.72 vs. 4.17 ± 2.74, = 0.41). No differences were detected in clinical pregnancy rate (50% vs. 54.8% vs. 50%, = 0.439), the live birth rate (86.3% vs. 82.0% vs. 87.8%, = 0.398), fertilization rate (64.1% vs. 64.4% vs. 64.7%, = 0.928), and biochemical pregnancy rate (4% vs. 4.5% vs. 7%, = 0.332) among the three groups.
The recurrence of hydrosalpinx after tubal ligation does not affect the outcomes of IVF/ICSI. It is not necessary to worry about the effect of recurrent hydrosalpinx on pregnancy outcomes of IVF/ICSI that may due to the spread of inflammation through lymphatic circulation or blood circulation.
本研究的目的是评估输卵管近端结扎和远端造口术后复发性输卵管积水对体外受精（IVF）或卵胞浆内单精子注射（ICSI）治疗结局的影响。
726例输卵管积水患者在IVF前接受了腹腔镜手术，纳入本研究。562例行输卵管近端结扎和远端造口术的患者被纳入A组。164例行输卵管切除术的病例被分为B组。A组进一步分为两个亚组。A1组146例患者出现输卵管积水复发。A2组416例患者未出现输卵管积水复发。我们比较了三组随后新鲜胚胎移植周期的妊娠结局。
三组在年龄、体重指数（23.56±3.27 vs. 23.13±3.42 vs. 23.63±3.73，P = 0.195）、基础激素水平（7.03±1.75 vs. 7.08±2.26 vs. 7.44±2.93，P = 0.195）、窦卵泡计数（12.25±5.92 vs. 12.63±5.71 vs. 11.70±4.98，P = 0.188）、促性腺激素（Gn）使用时间（11.19±2.1 vs. 10.93±1.84 vs. 10.79±2.03，P = 0.182）、Gn用量（2136.73±855.65 vs. 1997.15±724.72 vs. 2069.05±765.12，P = 0.14）、子宫内膜厚度（1.1±0.27 vs. 1.1±0.24 vs. 1.1±0.17，P = 0.352）、基础促卵泡激素（6.21±3.43 vs. 6.52±3.20 vs. 5.89±3.10，P = 0.1）、移植胚胎数（1.87±0.36 vs. 1.8
