Massafra Marco, Passalacqua Maria Ilenia, Lupo Giuseppe, Altavilla Giuseppe, Santarpia Mariacarmela
Department of Human Pathology "G. Barresi", Medical Oncology Unit, University of Messina, 98122, Messina, Italy.
Urol Case Rep. 2021 Jan;34:101461. doi: 10.1016/j.eucr.2020.101461. Epub 2020 Oct 21.
Capillary leak syndrome (CLS) is a rare disorder associated with an increased capillar permeability due to an endothelial damage, causing leakage of plasma and proteins into the interstitial compartment. CLS is characterized by rapidly developing edema, hypotension and hypoproteinemia. We observed CLS in a 54-year-old man affected by muscle-invasive bladder cancer who received neoadjuvant treatment with Cisplatin and Gemcitabine. Treatment with infusion of albumin and increasing corticosteroid doses and diuretics led to a complete regression of all signs and symptoms related to the disorder. Of note, the patient showed an objective complete response to chemotherapy and underwent radical surgery on schedule.
毛细血管渗漏综合征（CLS）是一种罕见的疾病，由于内皮损伤导致毛细血管通透性增加，引起血浆和蛋白质渗漏到间质腔隙。CLS的特征是迅速出现水肿、低血压和低蛋白血症。我们在一名54岁的肌肉浸润性膀胱癌男性患者中观察到了CLS，该患者接受了顺铂和吉西他滨的新辅助治疗。输注白蛋白、增加皮质类固醇剂量和使用利尿剂进行治疗后，与该疾病相关的所有体征和症状完全消退。值得注意的是，该患者对化疗表现出客观的完全缓解，并如期接受了根治性手术。
