Lu Qun, Wang Zhengyin, Yin Yuan, Zhao Yanrong, Tao Ping, Zhong Ping
Department of Laboratory Medicine, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Infectious Diseases, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Med (Lausanne). 2020 Sep 25;7:558545. doi: 10.3389/fmed.2020.558545. eCollection 2020.
Current evidence is controversial in the association between peripheral lymphocyte levels and the progression and mortality of Corona Virus Disease 2019 (COVID-19), and this meta-analysis aimed to clarify the association. A systematic search was conducted in public databases to identify all relevant studies, and the study-specific odds ratio (OR) and 95% confidence intervals (CI) were pooled. Finally, 16 studies were identified with a total of 1,873 progressive COVID-19 cases and 5,177 stable COVID-19 cases. In COVID-19 progression, lymphocyte levels showed a significant negative correlation (OR: 0.68, 95% CI: 0.51-0.89), but it was not significant in the subsets of CD3+ T cells (OR: 0.97, 95% CI: 0.93-1.02), CD4+ T cells (OR: 0.93, 95% CI: 0.80-1.08), CD8+ T cells (OR: 0.96, 95% CI: 0.92-1.00), B cells (OR: 0.98, 95% CI: 0.92-1.04), or NK cells (OR: 0.80, 95% CI: 0.61-1.04). In COVID-19 mortality, lymphocyte levels showed a significant negative correlation (OR: 0.41, 95% CI: 0.20-0.85), but it was not significant in the subsets of CD3+ T cells (OR: 0.95, 95% CI: 0.86-1.05), CD4+ T cells (OR: 1.06, 95% CI: 0.86-1.31), CD8+ T cells (OR: 0.38, 95% CI: 0.14-1.01), B cells (OR: 0.98, 95% CI: 0.92-1.04), or NK cells (OR: 0.80, 95% CI: 0.61-1.04). In conclusion, current evidence suggests a significant negative association of peripheral lymphocyte levels with COVID-19 progression and mortality, but it was not significant in the subsets of CD3+ T cells, CD4+ T cells, CD8+ T cells, B cells, and NK cells.
目前的证据对于外周淋巴细胞水平与2019冠状病毒病（COVID-19）的进展及死亡率之间的关联存在争议，而本荟萃分析旨在阐明这种关联。我们在公共数据库中进行了系统检索以识别所有相关研究，并汇总了各研究的比值比（OR）及95%置信区间（CI）。最终，我们确定了16项研究，其中共有1873例进展期COVID-19病例和5177例稳定期COVID-19病例。在COVID-19进展方面，淋巴细胞水平呈现显著负相关（OR：0.68，95%CI：0.51 - 0.89），但在CD3⁺ T细胞亚群（OR：0.97，95%CI：0.93 - 1.02）、CD4⁺ T细胞亚群（OR：0.93，95%CI：0.80 - 1.08）、CD8⁺ T细胞亚群（OR：0.96，95%CI：0.92 - 1.00）、B细胞亚群（OR：0.98，95%CI：0.92 - 1.04）或自然杀伤细胞亚群（OR：0.80，95%CI：0.61 - 1.04）中无显著相关性。在COVID-19死亡率方面，淋巴细胞水平呈现显著负相关（OR：0.41，95%CI：0.20 - 0.85），但在CD3⁺ T细胞亚群（OR：0.95，95%CI：0.86 - 1.05）、CD4⁺ T细胞亚群（OR：1.06，95%CI：0.86 - 1.31）、CD8⁺ T细胞亚群（OR：0.38，95%CI：0.14 - 1.01）、B细胞亚群（OR：0.98，95%CI：0.92 - 1.04）或自然杀伤细胞亚群（OR：0.80，95%CI：0.61 - 1.04）中无显著相关性。总之，目前的证据表明外周淋巴细胞水平与COVID-19的进展及死亡率存在显著负相关，但在CD3⁺ T细胞、CD4⁺ T细胞、CD8⁺ T细胞、B细胞和自然杀伤细胞亚群中无显著相关性。
