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帕金森病中的幻觉:对机制与治疗的新见解

Hallucinations in Parkinson's disease: new insights into mechanisms and treatments.

作者信息

Weil Rimona S, Reeves Suzanne

出版信息

Adv Clin Neurosci Rehabil. 2020 Jul 13;19(4):ONNS5189. doi: 10.47795/ONNS5189. eCollection 2020 Summer.

Abstract

Hallucinations are common in Parkinson's disease and can be distressing to patients and their families. They are associated with higher rates of nursing home placement and with increased mortality. Their underlying mechanisms have been elusive, but recent advances in network imaging provides some intriguing insights into possible underlying drivers. Treatment is complicated by risk of worsening Parkinson's motor symptoms and by higher rates of mortality with antipsychotics, but new therapeutic avenues are emerging that offer potential hope.

摘要

幻觉在帕金森病中很常见,会给患者及其家人带来困扰。幻觉与更高的养老院安置率和死亡率增加有关。其潜在机制一直难以捉摸,但网络成像的最新进展为可能的潜在驱动因素提供了一些有趣的见解。由于帕金森病运动症状恶化的风险以及抗精神病药物导致的更高死亡率,治疗变得复杂,但新的治疗途径正在出现,带来了潜在的希望。

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