Heim Beatrice, Djamshidian Atbin
Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, Innsbruck 6020, Austria.
Ther Adv Neurol Disord. 2025 Jul 28;18:17562864251356062. doi: 10.1177/17562864251356062. eCollection 2025.
Neuropsychiatric symptoms, such as depression, anxiety, cognitive changes, apathy or hallucinations are common in patients with Parkinson's disease (PD). They can appear at any stage of the disease and some symptoms may even be a harbinger of PD. These neuropsychiatric complications often become more pronounced as PD progresses and may worsen particularly during 'off-periods'. Moreover, neuropsychiatric symptoms are also frequently seen in patients with addictive behaviours, collectively called impulse control disorders, where insight is particularly low. In this narrative review, non-pharmacological as well as experimental and pragmatic pharmacological approaches are outlined to provide a deeper understanding of the best treatment strategy for these patients. Early detection as well as a tailored multidisciplinary approach is necessary to improve symptoms and ultimately the quality of life for patients and their family members.
神经精神症状，如抑郁、焦虑、认知改变、淡漠或幻觉，在帕金森病（PD）患者中很常见。它们可出现在疾病的任何阶段，有些症状甚至可能是PD的先兆。随着PD的进展，这些神经精神并发症往往会变得更加明显，尤其在“关期”可能会恶化。此外，神经精神症状在有成瘾行为（统称为冲动控制障碍）的患者中也很常见，这些患者的自知力特别低。在这篇叙述性综述中，概述了非药物以及实验性和实用性的药物治疗方法，以便更深入地了解这些患者的最佳治疗策略。早期检测以及量身定制的多学科方法对于改善症状并最终提高患者及其家庭成员的生活质量是必要的。
