Süleymanoğlu Muhammed, Rencüzoğulları İbrahim, Karabağ Yavuz, Çağdaş Metin, Yesin Mahmut, Gümüşdağ Ayça, Çap Murat, Gök Murat, Yıldız İbrahim
Department of Cardiology, Kafkas University Medical Faculty, Kars, Turkey.
Department of Cardiology, Diyarbakir Gazi Yasargil Training and Research Hospital, University of Health Sciences, Diyarbakir, Turkey.
Int J Cardiovasc Imaging. 2021 Jan;37(1):3-4. doi: 10.1007/s10554-020-01919-0. Epub 2020 Oct 24.
We have read with a great pleasure the letter of Yue J, et al. to the editor about our recent study which showed an association between atherogenic index of plasma and no-reflow in patients with ST segment elevation myocardial infarction who underwent primary percutaneous coronary intervention. Yue J, et al. raises concerns about the timing of blood collection, whether if it was taken before the emergency intervention or after. In emergency department, while performing intravenous line, the blood samples for blood biochemistry and whole blood count were also taken from the patients. Another concern of the author was the timing of left ventricular ejection fraction measurement (LVEF). LVEF measurements were obtained before the emergency intervention and some were after the intervention, but before the patient discharge. In our study we included the LVEF in our model, because we could not ignore that modeling which was comprehensively used in recent studies on relation of LVEF and no-reflow. We designed this statistical model not only for the no-reflow prediction but also for the explanation of the no-reflow pathophysiology. We thank the authors' letter for pointing out these issues that we hope to have addressed.
我们非常愉快地阅读了岳J等人致编辑的信，信中提及了我们最近的一项研究。该研究显示，在接受直接经皮冠状动脉介入治疗的ST段抬高型心肌梗死患者中，血浆致动脉粥样硬化指数与无复流现象之间存在关联。岳J等人对血液采集时间提出了疑问，即血液样本是在紧急干预之前还是之后采集的。在急诊科，在进行静脉穿刺时，也会从患者身上采集用于血液生化和全血细胞计数的血样。作者的另一个关注点是左心室射血分数（LVEF）的测量时间。LVEF测量是在紧急干预之前进行的，有些是在干预之后，但在患者出院之前。在我们的研究中，我们将LVEF纳入了模型，因为我们不能忽视最近关于LVEF与无复流关系的研究中广泛使用的建模方法。我们设计这个统计模型不仅是为了预测无复流，也是为了解释无复流的病理生理学。我们感谢作者的来信指出这些问题，我们希望已经对此进行了说明。
