National Health Laboratory Service and Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa.
Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Ann Clin Biochem. 2021 Mar;58(2):95-101. doi: 10.1177/0004563220972539. Epub 2020 Nov 20.
During the outbreak of coronavirus disease 2019 (COVID-19), many studies have investigated laboratory biomarkers in management and prognostication of COVID-19 patients, however to date, few have investigated arterial blood gas, acid-base and blood pressure patterns. The aim of the study is to assess the arterial blood gas and acid-base patterns, blood pressure findings and their association with the outcomes of COVID-19 patients admitted to an intensive care unit.
A single-centre retrospective, observational study in a dedicated COVID-19 intensive care unit in Cape Town, South Africa. Admission arterial blood gas, serum electrolytes, renal function and blood pressure readings performed on COVID-19 patients admitted between 26 March and 2 June 2020 were analysed and compared between survivors and non-survivors.
A total of 56 intensive care unit patients had admission arterial blood gas performed at the time of intensive care unit admission. An alkalaemia (pH > 7.45) was observed in 36 (64.3%) patients. A higher arterial pH (median 7.48 [interquartile range: 7.45-7.51] versus 7.46 [interquartile range: 7.40-7.48], = 0.049) and partial pressure of oxygen in arterial blood (median 7.9 kPa [interquartile range: 7.3-9.6] versus 6.5 kPa [interquartile range: 5.2-7.3], = <0.001) were significantly associated with survival. Survivors also tended to have a higher systolic blood pressure (median: 144 mmHg [interquartile range: 134-152] versus 139 mmHg [interquartile range: 125-142], = 0.078) and higher arterial HCO (median: 28.0 mmol/L [interquartile range: 25.7-28.8] versus 26.3 mmol/L [interquartile range: 24.3-27.9], = 0.059).
The majority of the study population admitted to intensive care unit had an alkalaemia on arterial blood gas. A higher pH and lower partial pressure of oxygen in arterial blood on arterial blood gas analysis were significantly associated with survival.
在 2019 年冠状病毒病（COVID-19）爆发期间，许多研究调查了 COVID-19 患者管理和预后的实验室生物标志物，但迄今为止，很少有研究调查动脉血气、酸碱和血压模式。本研究的目的是评估 COVID-19 患者入住重症监护病房（ICU）的动脉血气和酸碱模式、血压结果及其与结局的关系。
这是一项在南非开普敦专门的 COVID-19 ICU 进行的单中心回顾性观察性研究。分析并比较了 2020 年 3 月 26 日至 6 月 2 日期间入住 ICU 的 COVID-19 患者的入院时动脉血气、血清电解质、肾功能和血压读数，比较了存活者和非存活者之间的差异。
共有 56 名 ICU 患者在入住 ICU 时进行了入院时动脉血气检查。36 名（64.3%）患者存在碱血症（pH 值>7.45）。动脉 pH 值更高（中位数 7.48 [四分位距：7.45-7.51] 与 7.46 [四分位距：7.40-7.48]，=0.049）和动脉血中氧分压更高（中位数 7.9 kPa [四分位距：7.3-9.6] 与 6.5 kPa [四分位距：5.2-7.3]，=<0.001）与存活显著相关。存活者的收缩压（中位数：144mmHg [四分位距：134-152] 与 139mmHg [四分位距：125-142]，=0.078）和动脉 HCO3-（中位数：28.0mmol/L [四分位距：25.7-28.8] 与 26.3mmol/L [四分位距：24.3-27.9]，=0.059）也较高。
大多数入住 ICU 的研究人群的动脉血气检查显示存在碱血症。动脉血气分析显示 pH 值更高、动脉血中氧分压更低与存活显著相关。
