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面部骨折患者后续偏头痛风险:基于人群的队列研究。

Risk of Subsequent Migraines in Facial Fracture Patients: A Population-Based Cohort Study.

机构信息

School of Medicine, China Medical University, Taichung, Taiwan.

Department of Surgery, China Medical University Hospital, Taichung, Taiwan.

出版信息

Facial Plast Surg Aesthet Med. 2022 Jan-Feb;24(1):41-47. doi: 10.1089/fpsam.2020.0361. Epub 2020 Oct 26.

Abstract

Limited studies have discussed the association between facial fractures and subsequent migraines. In this study, we examined this association and the effect of facial fracture and surgery on the development of migraines. We selected 5034 patients with facial fractures and a matched cohort of 20,136 patients without facial fractures or facial-associated surgery with a history of migraine from the National Health Insurance database. Risk factors included age, gender, occupation (white-collar, blue-collar, and others), and comorbidities. Patients were frequency matched by age, gender, and index year. The incidence of migraine and the association between migraine development and facial surgery were identified by facial fracture location stratification. The incidence of migraines in the facial fracture cohort was 1.37-fold higher when compared with the comparison cohort (6.47 vs. 4.73 per 1000 person-years). There was a 1.31-fold risk of migraines in the adjusted hazard model and a 1.30-fold risk of migraines in the subdistribution hazard model (95% confidence interval [CI], 1.12-1.52 and 1.12-1.51, respectively). Malar/maxillary and nasal fractures showed 1.48- and 1.29-fold risks of migraines in the adjusted hazard model and subdistribution hazard model (95% CI, 1.16-1.89 and 1.05-1.59, respectively). There were no significant differences in migraine occurrence among patients who underwent surgery. Our findings indicated that malar/maxillary and nasal fractures were associated with a subsequent risk of migraines. There were no significant differences in migraine occurrence among patients who underwent surgery. Because of the retrospective nature of this study, further studies are warranted.

摘要

已有少量研究探讨了面部骨折与随后偏头痛之间的关联。在这项研究中,我们检验了这种关联以及面部骨折和手术对面部骨折患者偏头痛发展的影响。我们从全民健康保险数据库中选择了 5034 例面部骨折患者和 20136 例无面部骨折或面部相关手术且有偏头痛病史的匹配队列患者。风险因素包括年龄、性别、职业(白领、蓝领和其他)和合并症。患者按年龄、性别和指数年份进行频数匹配。通过面部骨折部位分层确定偏头痛的发生率和偏头痛发展与面部手术之间的关系。与对照组相比,面部骨折组偏头痛的发生率高 1.37 倍(每 1000 人年 6.47 比 4.73)。调整后的危险模型中偏头痛的风险比为 1.31(95%置信区间 [CI],1.12-1.52),亚分布危险模型中偏头痛的风险比为 1.30(95%CI,1.12-1.51)。颧骨/上颌骨和鼻骨骨折在调整后的危险模型和亚分布危险模型中的偏头痛风险分别为 1.48 倍和 1.29 倍(95%CI,1.16-1.89 和 1.05-1.59)。手术患者的偏头痛发生率无显著差异。我们的研究结果表明,颧骨/上颌骨和鼻骨骨折与随后偏头痛的风险增加有关。手术患者的偏头痛发生率无显著差异。由于本研究为回顾性研究,还需要进一步的研究。

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