Vest Noel, Sox-Harris Alex, Ilgen Mark, Humphreys Keith, Timko Christine
From the, Department of Psychiatry and Behavioral Sciences (NAV, KH, CT), Stanford University School of Medicine, Stanford, California, USA.
Veterans Affairs Palo Alto Health Care System, (AHSH, KH, CT), Palo Alto, California, USA.
Alcohol Clin Exp Res. 2020 Dec;44(12):2570-2578. doi: 10.1111/acer.14474. Epub 2020 Oct 26.
Patients with cooccurring mental health and substance use disorders often find it difficult to sustain long-term recovery. One predictor of recovery may be how depression symptoms and Alcoholics Anonymous (AA) involvement influence alcohol consumption during and after inpatient psychiatric treatment. This study utilized a parallel growth mixture model to characterize the course of alcohol use, depression, and AA involvement in patients with cooccurring diagnoses.
Participants were adults with cooccurring disorders (n = 406) receiving inpatient psychiatric care as part of a telephone monitoring clinical trial. Participants were assessed at intake, 3-, 9-, and 15-month follow-up.
A 3-class solution was the most parsimonious based upon fit indices and clinical relevance of the classes. The classes identified were high AA involvement with normative depression (27%), high stable depression with uneven AA involvement (11%), and low AA involvement with normative depression (62%). Both the low and high AA classes reduced their drinking across time and were drinking at less than half their baseline levels at all follow-ups. The high stable depression class reported an uneven pattern of AA involvement and drank at higher daily frequencies across the study timeline. Depression symptoms and alcohol use decreased substantially from intake to 3 months and then stabilized for 90% of patients with cooccurring disorders following inpatient psychiatric treatment.
These findings can inform future clinical interventions among patients with cooccurring mental health and substance use disorders. Specifically, patients with more severe symptoms of depression may benefit from increased AA involvement, whereas patients with less severe symptoms of depression may not.
同时患有精神健康和物质使用障碍的患者往往难以维持长期康复。康复的一个预测因素可能是抑郁症状和参加戒酒互助会(AA)如何影响住院精神科治疗期间及之后的酒精消费。本研究采用平行增长混合模型来描述同时患有这两种疾病的患者的酒精使用、抑郁和参加戒酒互助会的过程。
参与者为患有共病的成年人(n = 406),作为电话监测临床试验的一部分接受住院精神科护理。在入组时、随访3个月、9个月和15个月时对参与者进行评估。
根据拟合指数和类别与临床的相关性,三类解决方案最为简约。确定的类别为高戒酒互助会参与度且抑郁症状正常(27%)、高稳定抑郁且戒酒互助会参与度不均衡(11%)、低戒酒互助会参与度且抑郁症状正常(62%)。低戒酒互助会参与度和高戒酒互助会参与度这两类随着时间推移饮酒量均减少,在所有随访中饮酒量均低于基线水平的一半。高稳定抑郁类别报告了戒酒互助会参与度不均衡的模式,且在整个研究时间线内每日饮酒频率更高。抑郁症状和酒精使用从入组到3个月大幅下降,然后在住院精神科治疗后90%的共病患者中趋于稳定。
这些发现可为未来针对同时患有精神健康和物质使用障碍患者的临床干预提供参考。具体而言,抑郁症状更严重的患者可能会从增加戒酒互助会参与度中受益,而抑郁症状较轻的患者可能不会。