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Harnessing the Antiinflammatory Power of MyD88 to Reduce Allergic Fungal Inflammation?

作者信息

Gaurav Rohit, Poole Jill A

机构信息

Department of Internal Medicine University of Nebraska Medical Center Omaha, Nebraska.

出版信息

Am J Respir Cell Mol Biol. 2021 Jan;64(1):1-3. doi: 10.1165/rcmb.2020-0442ED.

DOI:10.1165/rcmb.2020-0442ED
PMID:33105084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7780992/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ccc/7780992/608ba549bde5/rcmb.2020-0442EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ccc/7780992/608ba549bde5/rcmb.2020-0442EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ccc/7780992/608ba549bde5/rcmb.2020-0442EDf1.jpg

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本文引用的文献

1
Recognition by Dendritic Cells Negatively Regulates Allergic Lung Inflammation through a TLR2/MyD88 Pathway.树突状细胞的识别通过 TLR2/MyD88 通路负调节过敏性肺炎症。
Am J Respir Cell Mol Biol. 2021 Jan;64(1):39-49. doi: 10.1165/rcmb.2020-0083OC.
2
Organic dust-induced lung injury and repair: Bi-directional regulation by TNFα and IL-10.有机粉尘诱导的肺损伤与修复：TNFα 和 IL-10 的双向调控
J Immunotoxicol. 2020 Dec;17(1):153-162. doi: 10.1080/1547691X.2020.1776428.
3
Allergen-Specific Immunotherapy With Liposome Containing CpG-ODN in Murine Model of Asthma Relies on MyD88 Signaling in Dendritic Cells.
含 CpG-ODN 的脂质体变应原特异性免疫疗法依赖于树突状细胞中的 MyD88 信号在哮喘小鼠模型中的作用。
Front Immunol. 2020 Apr 23;11:692. doi: 10.3389/fimmu.2020.00692. eCollection 2020.
4
Ovalbumin-sensitized mice have altered airway inflammation to agriculture organic dust.卵清蛋白致敏的小鼠对农业有机粉尘的气道炎症发生改变。
Respir Res. 2019 Mar 7;20(1):51. doi: 10.1186/s12931-019-1015-0.
5
MyD88 controls airway epithelial Muc5ac expression during TLR activation conditions from agricultural organic dust exposure.MyD88 在农业有机粉尘暴露的 TLR 激活条件下控制气道上皮细胞 Muc5ac 的表达。
Am J Physiol Lung Cell Mol Physiol. 2019 Feb 1;316(2):L334-L347. doi: 10.1152/ajplung.00206.2018. Epub 2018 Oct 25.
6
Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.阿米什和哈特派农场儿童的先天免疫与哮喘风险
N Engl J Med. 2016 Aug 4;375(5):411-421. doi: 10.1056/NEJMoa1508749.
7
Triggering Dectin-1-Pathway Alone Is Not Sufficient to Induce Cytokine Production by Murine Macrophages.仅激活小甘露糖受体途径不足以诱导小鼠巨噬细胞产生细胞因子。
PLoS One. 2016 Feb 3;11(2):e0148464. doi: 10.1371/journal.pone.0148464. eCollection 2016.
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IL-10 Production in Macrophages Is Regulated by a TLR-Driven CREB-Mediated Mechanism That Is Linked to Genes Involved in Cell Metabolism.巨噬细胞中白细胞介素-10的产生受Toll样受体驱动的CREB介导机制调控，该机制与参与细胞代谢的基因相关。
J Immunol. 2015 Aug 1;195(3):1218-32. doi: 10.4049/jimmunol.1500146. Epub 2015 Jun 26.
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Role of Aspergillus fumigatus in Triggering Protease-Activated Receptor-2 in Airway Epithelial Cells and Skewing the Cells toward a T-helper 2 Bias.烟曲霉在触发气道上皮细胞中的蛋白酶激活受体-2并使细胞偏向2型辅助性T细胞倾向方面的作用。
Am J Respir Cell Mol Biol. 2016 Jan;54(1):60-70. doi: 10.1165/rcmb.2015-0062OC.
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Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps.人浆细胞样树突状细胞对烟曲霉菌丝的识别由dectin-2介导，并导致细胞外陷阱的形成。
PLoS Pathog. 2015 Feb 6;11(2):e1004643. doi: 10.1371/journal.ppat.1004643. eCollection 2015 Feb.