全氟和多氟烷基物质与消防员的心血管代谢标志物。
Per- and Polyfluoroalkyl Substance and Cardio Metabolic Markers in Firefighters.
机构信息
Department of Population and Public Health Sciences, Boonshoft School of Medicine, Wright State University, Dayton, Ohio (Dr Khalil), School of Public Health, and School of Medicine, West Virginia University, Morgantown, West Virginia (Dr Ducatman), UA Health Sciences & Bio5 Institute, Statistics Consulting Laboratory, University of Arizona, Tucson, Arizona (Mr Sinari, Dr Billheimer), Epidemiology and Biostatistics Department, University of Arizona, Tucson, Arizona (Dr Hu), Department of Community, Environment and Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona (Ms Littau, Dr Burgess).
出版信息
J Occup Environ Med. 2020 Dec;62(12):1076-1081. doi: 10.1097/JOM.0000000000002062.
OBJECTIVE
To evaluate if serum polyfluoroalkyl substances (PFAS) were associated with cardiometabolic markers.
METHODS
Serum PFAS were evaluated in 38 Arizona firefighters and 49 participants from the 2009 to 2010 National Health and Nutrition Examination Survey (NHANES). Cardiometabolic markers including carotid intima-medial thickness (CIMT) were measured in the firefighters.
RESULTS
Firefighters had elevated perfluorohexane sulfonic acid (PFHxS) and lower perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA) compared to NHANES participants; for nine of the other 12 PFAS the values were not significantly different. There were significant negative associations among firefighters between perfluorodecanoic acid (PFDeA) and total cholesterol and PFUA and interleukin-6. PFAS concentrations were not associated with CIMT.
CONCLUSION
PFHxS levels were elevated in firefighters compared to NHANES subjects. Serum PFAS concentrations were not associated with increased cardiometabolic risk measures in this population of firefighters.
目的
评估血清多氟烷基物质 (PFAS) 是否与心血管代谢标志物有关。
方法
在 38 名亚利桑那州消防员和 2009 年至 2010 年全国健康和营养检查调查 (NHANES) 的 49 名参与者中评估血清 PFAS。在消防员中测量心血管代谢标志物，包括颈动脉内膜中层厚度 (CIMT)。
结果
与 NHANES 参与者相比，消防员的全氟己烷磺酸 (PFHxS) 升高，而全氟壬酸 (PFNA) 和全氟十一烷酸 (PFUA) 降低；对于其他 12 种 PFAS 中的 9 种，其值没有显着差异。在消防员中，全氟癸酸 (PFDeA) 与总胆固醇和 PFUA 与白细胞介素 6 之间存在显着负相关。PFAS 浓度与 CIMT 无关。
结论
与 NHANES 参与者相比，消防员的 PFHxS 水平升高。在这群消防员中，血清 PFAS 浓度与增加的心血管代谢风险指标无关。
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