Li Ying, Fletcher Tony, Mucs Daniel, Scott Kristin, Lindh Christian H, Tallving Pia, Jakobsson Kristina
Division of Occupational and Environmental Medicine, Department of Public Health and Community Medicine, University of Gothenburg, Gothenburg, Sweden.
Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, UK.
Occup Environ Med. 2018 Jan;75(1):46-51. doi: 10.1136/oemed-2017-104651. Epub 2017 Nov 13.
Municipal drinking water contaminated with perfluorinated alkyl acids had been distributed to one-third of households in Ronneby, Sweden. The source was firefighting foam used in a nearby airfield since the mid-1980s. Clean water was provided from 16 December 2013.
To determine the rates of decline in serum perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), and their corresponding half-lives.
Up to seven blood samples were collected between June 2014 and September 2016 from 106 participants (age 4-84 years, 53% female).
Median initial serum concentrations were PFHxS, 277 ng/mL (range 12-1660); PFOS, 345 ng/mL (range 24-1500); and PFOA, 18 ng/mL (range 2.4-92). The covariate-adjusted average rates of decrease in serum were PFHxS, 13% per year (95% CI 12% to 15%); PFOS, 20% per year (95% CI 19% to 22%); and PFOA, 26% per year (95% CI 24% to 28%). The observed data are consistent with a first-order elimination model. The mean estimated half-life was 5.3 years (95% CI 4.6 to 6.0) for PFHxS, 3.4 years (95% CI 3.1 to 3.7) for PFOS and 2.7 years (95% CI 2.5 to 2.9) for PFOA. The interindividual variation of half-life was around threefold when comparing the 5th and 95th percentiles. There was a marked sex difference with more rapid elimination in women for PFHxS and PFOS, but only marginally for PFOA.
The estimated half-life for PFHxS was considerably longer than for PFOS and PFOA. For PFHxS and PFOS, the average half-life is shorter than the previously published estimates. For PFOA the half-life is in line with the range of published estimates.
瑞典吕勒奥市三分之一家庭的市政饮用水被全氟烷基酸污染。污染源是自20世纪80年代中期以来附近机场使用的消防泡沫。2013年12月16日起开始供应清洁水。
确定血清中全氟己烷磺酸（PFHxS）、全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）的下降速率及其相应半衰期。
2014年6月至2016年9月期间，从106名参与者（年龄4 - 84岁，53%为女性）身上采集了多达7份血样。
血清中PFHxS的初始中位数浓度为277 ng/mL（范围12 - 1660）；PFOS为345 ng/mL（范围24 - 1500）；PFOA为18 ng/mL（范围2.4 - 92）。经协变量调整后的血清平均下降速率为：PFHxS每年13%（95%置信区间12%至15%）；PFOS每年20%（95%置信区间19%至22%）；PFOA每年26%（95%置信区间24%至28%）。观察到的数据与一级消除模型一致。PFHxS的平均估计半衰期为5.3年（95%置信区间4.6至6.0），PFOS为3.4年（95%置信区间3.1至3.7），PFOA为2.7年（95%置信区间2.5至2.9）。比较第5和第95百分位数时，半衰期的个体间差异约为三倍。存在明显的性别差异，女性中PFHxS和PFOS的消除速度更快，但PFOA仅略有差异。
PFHxS的估计半衰期比PFOS和PFOA长得多。对于PFHxS和PFOS，平均半衰期短于先前公布的估计值。对于PFOA，半衰期与公布的估计范围一致。
