Kang K, Shao Y, Song G D
Department of Burns and Plastic Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China.
Zhonghua Shao Shang Za Zhi. 2020 Oct 20;36(10):971-974. doi: 10.3760/cma.j.cn501120-20200204-00043.
To date, skin substitute that can provide permanent wound closure is still autologous tissue-engineered skin using autologous skin cells as seed cells. The development of cultured epithelial autograft has experienced a long and tortuous process. Autologous tissue-engineered composite skin is closer to autologous split-thickness skin graft in terms of structure, function, and efficacy, which has become a research focus in recent years. Based on the actual status of research on tissue-engineered skin application, this paper reviewed the main research progresses and existing problems, and the prospect of research and development and clinical application of autologous tissue-engineered skin as permanent graft in order to provide a reference for the improvement and application of autologous tissue-engineered skin.
迄今为止，能够实现永久性伤口闭合的皮肤替代物仍然是使用自体皮肤细胞作为种子细胞的自体组织工程皮肤。培养的上皮自体移植的发展经历了漫长而曲折的过程。自体组织工程复合皮肤在结构、功能和疗效方面更接近自体中厚皮片移植，这已成为近年来的研究热点。基于组织工程皮肤应用研究的实际状况，本文综述了主要研究进展和存在的问题，以及自体组织工程皮肤作为永久性移植物的研发和临床应用前景，以期为自体组织工程皮肤的改进和应用提供参考。
