Xiao S C, Zheng Y J
Burn Institute of PLA, Department of Burn Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Zhonghua Shao Shang Za Zhi. 2020 Mar 20;36(3):166-170. doi: 10.3760/cma.j.cn501120-20191202-00449.
Autologous split-thickness skin grafting is still an important procedure for the repair of skin defect. However, there are some obvious limitations, such as new injury to skin donor sites and insufficient skin source, etc. It is an ideal goal to develop tissue-engineered skin to realize permanent replacement of skin defect. After decades of development, a variety of tissue-engineered skins have been put into the market for applications, but it is still a long way to achieve regenerative repair of skin defect. In this article, we summarize the status of various tissue-engineered skins, and then make a preliminary discussion on the opportunities and challenges on development of tissue-engineered skin.
自体中厚皮片移植仍是修复皮肤缺损的重要手术。然而，它存在一些明显的局限性，如供皮区新的损伤和皮肤来源不足等。开发组织工程皮肤以实现皮肤缺损的永久性替代是一个理想目标。经过几十年的发展，多种组织工程皮肤已投放市场应用，但实现皮肤缺损的再生修复仍有很长的路要走。在本文中，我们总结了各种组织工程皮肤的现状，然后对组织工程皮肤发展面临的机遇和挑战进行了初步探讨。
