Wilcox C S, Peart W S
Department of Medicine, University of Florida College of Medicine, Gainesville 32610.
Am J Physiol. 1987 Oct;253(4 Pt 2):F734-41. doi: 10.1152/ajprenal.1987.253.4.F734.
Renal vascular resistance (RVR) was related to intrarenal release of renin (RR) and angiotensin II (ANG II) during increases in plasma osmolality (Posmol) or chloride (PCl). Intrarenal infusions of 1.232 M solutions given to in situ kidneys increased Posmol by 7-18%. Hypertonic dextrose (n = 8) reduced RVR (P less than 0.005) but increased RR into plasma (P less than 0.01) and increased lymph renin (LR) (P less than 0.05). The response to hypertonic Na acetate (n = 5) was similar, but hypertonic NaCl (n = 9) increased RVR (P less than 0.02) without changing RR. During infusion of arachidonic acid (AA), hypertonic NaCl increased RVR (P less than 0.02) but decreased RR into plasma and decreased LR (P less than 0.05). Overall group mean changes in RVR were inversely related to LR (r = -0.96; P less than 0.01). An increase in PCl of 12 +/- 1 mmol/l was induced in denervated kidneys by changing an intrarenal 0.616 M infusion of Na acetate to NaCl. Hyperchloremia increased RVR from 14 +/- 2 to 19 +/- 2 mmHg . ml-1 . min-1 . kg-1 (P less than 0.01), reduced GFR from 1.4 +/- 0.1 to 1.1 +/- 0.1 ml . min-1 . kg-1 (P less than 0.01), and reduced ANG II (pg/ml) in renal venous plasma (55 +/- 6 to 35 +/- 6; P less than 0.05) and lymph (366 +/- 111 to 209 +/- 53; P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
在血浆渗透压（Posmol）或氯离子（PCl）升高期间，肾血管阻力（RVR）与肾内肾素（RR）和血管紧张素II（ANG II）的释放有关。向原位肾脏输注1.232 M溶液可使Posmol升高7 - 18%。高渗葡萄糖（n = 8）降低了RVR（P < 0.005），但使血浆RR升高（P < 0.01）并使淋巴肾素（LR）升高（P < 0.05）。对高渗醋酸钠（n = 5）的反应相似，但高渗氯化钠（n = 9）增加了RVR（P < 0.02），而RR未改变。在输注花生四烯酸（AA）期间，高渗氯化钠增加了RVR（P < 0.02），但降低了血浆RR并降低了LR（P < 0.05）。RVR的总体组平均变化与LR呈负相关（r = -0.96；P < 0.01）。通过将肾内0.616 M醋酸钠输注改为氯化钠，使去神经支配的肾脏中的PCl升高12±1 mmol/l。高氯血症使RVR从14±2升高至19±2 mmHg·ml-1·min-1·kg-1（P < 0.01），使肾小球滤过率（GFR）从1.4±0.1降低至1.1±0.1 ml·min-1·kg-1（P < 0.01），并降低了肾静脉血浆（55±6至35±6；P < 0.05）和淋巴中的ANG II（pg/ml）（366±111至209±53；P < 0.05）。（摘要截断于250字）
