Nguyen-Dinh P, Greenberg A E, Kabote N, Davachi F, Goussard B, Embonga B
Division of Parasitic Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
Am J Trop Med Hyg. 1987 Sep;37(2):217-9. doi: 10.4269/ajtmh.1987.37.217.
In June 1986, Plasmodium falciparum parasites were collected from 33 children presenting at the Mama Yemo Hospital in Kinshasa (Zaire) and were successfully tested in vitro by a 48-hr reinvasion test for their susceptibility to various antimalarial drugs. In vitro resistance to chloroquine was found in 82% of the isolates, a marked increase over findings obtained by the same technique 3 years ago in Kinshasa. In vitro chloroquine resistance was not associated with a history of previous drug intake. The inhibitory endpoints for quinine varied from 0.03 to 1 microM, and correlated with the chloroquine endpoints in the corresponding isolates (r = 0.64). Pyrimethamine resistance in vitro was demonstrated in 52% of the isolates tested.
1986年6月，从金沙萨（扎伊尔）耶莫妈妈医院就诊的33名儿童身上采集了恶性疟原虫，并通过48小时再侵袭试验对其对各种抗疟药物的敏感性进行了体外成功检测。在82%的分离株中发现了对氯喹的体外抗性，这比3年前在金沙萨用相同技术获得的结果有显著增加。体外氯喹抗性与既往用药史无关。奎宁的抑制终点在0.03至1微摩尔之间，并且与相应分离株中的氯喹终点相关（r = 0.64）。在所检测的分离株中，52%表现出对乙胺嘧啶的体外抗性。
