Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Region Västra Götaland, Sahlgrenska University Hospital, Department of Rheumatology, Gothenburg, Sweden.
Rheumatology (Oxford). 2021 Apr 6;60(4):1804-1813. doi: 10.1093/rheumatology/keaa460.
To study baseline serum hepatocyte growth factor (s-HGF) as a predictor of spinal radiographic progression overall and by sex and to analyse factors correlated to changes in s-HGF in patients with AS.
At baseline and the 5-year follow-up, s-HGF was analysed with ELISA. Spinal radiographs were graded according to modified Stoke Ankylosing Spondylitis Spinal Score. Radiographic progression was defined as ≥2 modified Stoke Ankylosing Spondylitis Spinal Score units/5 years or development of ≥1 syndesmophyte. Logistic regression analyses were used.
Of 204 baseline participants, 163 (80%) completed all examinations at the 5-year follow-up (54% men). Baseline s-HGF was significantly higher in men who developed ≥1 syndesmophyte compared with non-progressors, median (interquartile range) baseline s-HGF 1551 (1449-1898) vs 1436 (1200-1569) pg/ml, P = 0.003. The calculated optimal cut-off point for baseline s-HGF ≥1520 pg/ml showed a sensitivity of 70%, a specificity of 69% and univariate odds radio (95% CI) of 5.25 (1.69, 14.10) as predictor of development of ≥1 new syndesmophyte in men. Baseline s-HGF ≥1520 pg/ml remained significantly associated with development of ≥1 new syndesmophyte in men in an analysis adjusted for the baseline variables age, smoking, presence of syndesmophytes and CRP, odds radio 3.97 (1.36, 11.60). In women, no association with HGF and radiographic progression was found. Changes in s-HGF were positively correlated with changes in ESR and CRP.
In this prospective cohort study elevated s-HGF was shown to be associated with development of new syndesmophytes in men with AS.
研究基线血清肝细胞生长因子（s-HGF）作为总体和按性别预测脊柱放射学进展的指标，并分析与 AS 患者 s-HGF 变化相关的因素。
在基线和 5 年随访时，使用 ELISA 分析 s-HGF。脊柱 X 线片根据改良 Stoke 强直性脊柱炎脊柱评分进行分级。放射学进展定义为≥2 个改良 Stoke 强直性脊柱炎脊柱评分单位/5 年或≥1 个骨桥形成。使用逻辑回归分析。
在 204 名基线参与者中，有 163 名（80%）在 5 年随访时完成了所有检查（54%为男性）。与非进展者相比，出现≥1 个骨桥形成的男性基线 s-HGF 明显较高，中位数（四分位距）基线 s-HGF 为 1551（1449-1898）比 1436（1200-1569）pg/ml，P=0.003。基线 s-HGF≥1520pg/ml 的最佳截断值显示出 70%的敏感性、69%的特异性和单变量优势比（95%CI）为 5.25（1.69, 14.10），作为男性出现≥1 个新骨桥形成的预测因子。在调整基线变量年龄、吸烟、骨桥形成和 CRP 后，基线 s-HGF≥1520pg/ml 与男性出现≥1 个新骨桥形成仍显著相关，优势比为 3.97（1.36, 11.60）。在女性中，未发现 HGF 与放射学进展之间存在关联。s-HGF 的变化与 ESR 和 CRP 的变化呈正相关。
在这项前瞻性队列研究中，升高的 s-HGF 与男性 AS 患者新骨桥形成的发展相关。
