II Department of Radiology, Medical University of Warsaw, Warsaw, Poland.
Faculty of Biomedical Engineering, Silesian University of Technology, Zabrze, Poland.
J Anat. 2021 Mar;238(3):765-784. doi: 10.1111/joa.13338. Epub 2020 Oct 27.
The goal of this study was to analyze trends in the geometric parameters of blood vessels with age in a randomly selected group of 200 computed tomography angiography studies of radiologically healthy individuals using dedicated statistical techniques. A quantitative description of cerebral vascular geometry with numerical parameters (bifurcation angle, branching angle, co-planarity index, average curvature, and average torsion) was proposed. The changes and variability in geometry were analyzed according to age. The bifurcation angle, branching angle, and average curvature increased with age, whereas the co-planarity index and average torsion decreased with age. For equal-diameter branches, women comparing to men presented lower bifurcation angles in the 4th decade of life, and lower values for the co-planarity index in the 3rd and 4th decades of life. In non-equal-diameter branches, the opposite relationship was observed for bifurcation angle in the 4th decade of life comparing both groups. All analyzed parameters showed clearly visible trends with patient age. Deviations in specific decades of life were detected; these deviations could be linked to the development of aneurysms in specific age groups.
本研究旨在使用专门的统计技术，分析随机选择的 200 例影像学健康个体的计算机断层血管造影研究中血管的几何参数随年龄的变化趋势。提出了用数值参数（分叉角、分支角、共面性指数、平均曲率和平均扭转）对脑血管几何形状进行定量描述。根据年龄分析了几何形状的变化和可变性。分叉角、分支角和平均曲率随年龄增加而增加，而共面性指数和平均扭转随年龄增加而减小。对于等直径分支，与男性相比，女性在生命的第四个十年呈现出较低的分叉角，而在生命的第三个和第四个十年呈现出较低的共面性指数。在非等直径分支中，两组在生命的第四个十年观察到相反的关系。所有分析的参数都表现出与患者年龄明显相关的趋势。在特定的生命十年中发现了偏差；这些偏差可能与特定年龄组的动脉瘤发展有关。
