Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Ave., Nanshan District, Shenzhen, 518055, People's Republic of China.
Department of Cardiovascular Surgery, Henan Province People's Hospital, Fuwai Central China Cardiovascular Hospital, Zhengzhou University People's Hospital and Medical School of Henan University, Zhengzhou, 450000, Henan Province, People's Republic of China.
Biomed Eng Online. 2018 Mar 2;17(1):30. doi: 10.1186/s12938-018-0458-8.
Many studies have demonstrated that the geometry of the carotid bifurcation enables prediction of blood flow variation associated with atherosclerotic plaque formation. The phase angle between the arterial wall circumferential strain and its instantaneous wall shear stress is known as stress phase angle (SPA). This parameter is used to evaluate hemodynamic factors of atherogenesis. Note that SPA can be numerically computed for the purpose of locating atherosclerosis in different artery geometries. However, there is no experimental data to verify its role in the location of atherosclerosis in different artery geometries. In this study, we use an ultrasonic biomechanical method to experimentally evaluate the role of SPA for locating atherosclerosis in carotid bifurcation.
For carotid anthropomorphic vascular phantom experiments, the SPAs of common carotid arteries (CCAs), external carotid arteries (ECAs) and internal carotid arteries (ICAs) are - 148.53 ± 6.92°, - 153.95 ± 5.11°, and - 238.69 ± 1.72°, respectively. The corresponding SPAs are - 173.47 ± 0.065°, - 115.57 ± 4.83° and - 233.9 ± 8.12° for the polyvinyl alcohol (PVA-c) phantoms. In vivo mouse experiments indicated that the wall shear stress and circumferential strain were out of phase in the ICAs (- 280.08 ± 13.12°) to a greater extent as compared to CCAs (- 141.97 ± 8.03°) and ECAs (- 170.07 ± 9.24°).
The results suggested that SPA may be a useful indicator to locate the atherosclerosis position in carotid bifurcation.
许多研究表明，颈动脉分叉处的几何形状可以预测与动脉粥样硬化斑块形成相关的血流变化。动脉壁周向应变及其瞬时壁切应力之间的相位角称为应相角（SPA）。该参数用于评估动脉粥样硬化形成的血流动力学因素。需要注意的是，SPA 可以通过数值计算来定位不同动脉几何形状中的动脉粥样硬化。然而，目前尚无实验数据验证 SPA 在不同动脉几何形状中定位动脉粥样硬化的作用。在本研究中，我们使用超声生物力学方法实验评估 SPA 在颈动脉分叉处定位动脉粥样硬化中的作用。
对于颈动脉仿体血管实验，颈总动脉（CCA）、颈外动脉（ECA）和颈内动脉（ICA）的 SPA 分别为-148.53±6.92°、-153.95±5.11°和-238.69±1.72°。聚乙烯醇（PVA-c）仿体的相应 SPA 分别为-173.47±0.065°、-115.57±4.83°和-233.9±8.12°。体内小鼠实验表明，ICA 中的壁切应力和周向应变相位差较大（-280.08±13.12°），而 CCA（-141.97±8.03°）和 ECA（-170.07±9.24°）相位差较小。
研究结果表明 SPA 可能是定位颈动脉分叉处动脉粥样硬化位置的有用指标。
