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[根据风险因素对新冠肺炎确诊患者的评估]

[Evaluation of Patients Diagnosed with COVID-19 in Terms of Risk Factors].

作者信息

Günal Özgür, Türe Eda, Bayburtlu Meryem, Arslan Uğur, Demirağ Mehmet Derya, Taşkın Mehmet Hakan, Kılıç Sırrı

机构信息

Health Sciences University, Samsun Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Samsun, Turkey.

Health Sciences University, Samsun Training and Research Hospital, Clinic of Family Medicine, Samsun, Turkey.

出版信息

Mikrobiyol Bul. 2020 Oct;54(4):575-582. doi: 10.5578/mb.69811.

Abstract

Coronaviruses are RNA viruses that can cause disease in the upper and lower respiratory tract in humans and animals. Lately, a new coronavirus causing pneumonia cases was detected in Wuhan, China in December 2019. Soon after, the name of the virus was identified as the "severe acute respiratory syndrome coronavirus-2", and the World Health Organization named the disease coronavirus disease-2019 (COVID-19). In our country, the first cases began to appear in the second week of March. In this study, we aimed to investigate the demographic characteristics and risk factors of patients with the diagnosis of COVID-19. A total of 100 patients (53 female and 47 male) were included in our study. The patients included in the study were randomly selected from the registration system and their information was evaluated retrospectively. The mean age of the patients was 54.42 (Age range= 20-90). When the risk factors for catching the disease were evaluated; it was determined that there was at least one risk factor in 46 patients; 30 patients had close contact with the COVID-19 patient in the social environment (30%) and 16 patients had a travel history outside the city in the last 14 days (16%). The most common symptoms in our patients were; cough (93%), fever (42%), dyspnea (22%), weakness (8%), sore throat (7%), diarrhea (6%), headache (5%) and sputum (2%). The most common comorbid conditions in our patients were detected as hypertension (42%), diabetes mellitus (DM) (21%), congestive heart failure (10%), allergic asthma (7%), chronic obstructive pulmonary disease (6%), rheumatoid arthritis (3%), coronary artery disease (2%), solid organ tumour (2%), depression (1%) and epilepsy (1%). The mean age of our 15 patients who were monitored in intensive care unit was 65 y (± 11.46), the mean age of 85 patients followed in the service was 52.55 (± 16.35) and this difference was statistically significant (p= 0.006). When these two groups were compared in terms of comorbid diseases, the presence of DM was 40% higher (n= 6) in intensive care patients, and this difference was statistically significant (p= 0.05). In addition, the majority [11 patients (73%)] of the patients hospitalized in the intensive care unit were male (p= 0.03). When smoking was evaluated as a risk factor for serious illness, 4 of 11 patients (26%) in intensive care unit had a smoking history, while none of the patients who have died due to COVID-19 had a smoking history. These findings suggested to us that smoking does not increase the severity of COVID-19 disease. As a result, knowledge about the disease should be increased rapidly by sharing the studies on risk factors, transmission routes and clinical features of COVID-19 infection, which affects the whole world.

摘要

冠状病毒是一种RNA病毒,可导致人类和动物的上、下呼吸道疾病。最近,2019年12月在中国武汉检测到一种导致肺炎病例的新型冠状病毒。此后不久,该病毒被命名为“严重急性呼吸综合征冠状病毒2”,世界卫生组织将该疾病命名为冠状病毒病-2019(COVID-19)。在我国,首例病例于3月的第二周开始出现。在本研究中,我们旨在调查COVID-19确诊患者的人口统计学特征和危险因素。我们的研究共纳入了100例患者(53例女性和47例男性)。纳入研究的患者是从登记系统中随机选取的,并对他们的信息进行回顾性评估。患者的平均年龄为54.42岁(年龄范围=20-90岁)。在评估感染该疾病的危险因素时;确定46例患者至少有一个危险因素;30例患者在社交环境中与COVID-19患者有密切接触(30%),16例患者在过去14天内有出城旅行史(16%)。我们患者中最常见的症状是;咳嗽(93%)、发热(42%)、呼吸困难(22%)、乏力(8%)、咽痛(7%)、腹泻(6%)、头痛(5%)和咳痰(2%)。我们患者中最常见的合并症被检测为高血压(42%)、糖尿病(DM)(21%)、充血性心力衰竭(10%)、过敏性哮喘(7%)、慢性阻塞性肺疾病(6%)、类风湿性关节炎(3%)、冠状动脉疾病(2%)、实体器官肿瘤(2%)、抑郁症(1%)和癫痫(1%)。在重症监护病房接受监测的15例患者的平均年龄为65岁(±11.46),在普通病房接受随访的85例患者的平均年龄为52.55岁(±16.35),这种差异具有统计学意义(p=0.006)。当比较这两组患者的合并症时,重症监护患者中DM的发生率高40%(n=6),这种差异具有统计学意义(p=0.05)。此外,在重症监护病房住院的患者中,大多数[11例患者(73%)]为男性(p=0.03)。当将吸烟评估为重症疾病的危险因素时,重症监护病房的11例患者中有4例(26%)有吸烟史,而因COVID-19死亡的患者中无一例有吸烟史。这些发现向我们表明,吸烟不会增加COVID-19疾病的严重程度。因此,应通过分享关于影响全球的COVID-19感染的危险因素、传播途径和临床特征的研究,迅速增加对该疾病的了解。

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