Zhang Jing, Guo Bin, Young David James, Li Hong-Xi
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
College of Engineering, Information Technology and Environment, Charles Darwin University, Darwin NT 0909, Australia.
Dalton Trans. 2020 Nov 17;49(44):15527-15547. doi: 10.1039/d0dt03282d.
Ru-Catalyzed acceptorless dehydrogenative coupling (ADC) and auto-transfer-hydrogenative (ATH) reactions are effective, versatile transformations for the constructions of N-heteroaromatic compounds from alcohols. Water and hydrogen are the by-products and the starting alcohols are less toxic, more readily available and more easily handled than their halogenated counterparts. A variety of homogeneous ruthenium catalysts, alcohols and partner-substrates such as amines, ammonia, amidines and nitriles, have been used to build N-heteroaromatic compounds in one-pot, multi-step syntheses. This review details recently reported Ru catalysts employed for these reactions, describing the scope of each methodology, proposed reaction mechanisms, regioselectivity of coupling and applications in synthesis.
钌催化的无受体脱氢偶联（ADC）和自动转移氢化（ATH）反应是从醇类构建氮杂芳族化合物的有效、通用的转化反应。水和氢气是副产物，起始醇类比其卤代对应物毒性更小、更容易获得且更易于处理。多种均相钌催化剂、醇类以及诸如胺、氨、脒和腈等伙伴底物已被用于一锅多步合成中构建氮杂芳族化合物。本综述详细介绍了最近报道的用于这些反应的钌催化剂，描述了每种方法的适用范围、提出的反应机理、偶联的区域选择性以及在合成中的应用。
