Instituto Aragonés de Ciencias de la Salud (IACS) & Aragon Institute for Health Research (IIS Aragón), Zaragoza, Spain.
Placental pathophysiology & fetal programming research group, B05 DGA & GIIS-028 del IISA.
Epigenomics. 2020 Oct;12(20):1769-1782. doi: 10.2217/epi-2019-0346. Epub 2020 Oct 27.
The aim of this study was to determine if alterations in DNA methylation in the human placenta would support suspected preterm labor as a pathologic insult associated with diminished placental health. We evaluated placental DNA methylation at seven differentially methylated in placental pathologies using targeted bisulfite sequencing, in placentas associated with preterm labor (term birth after suspected preterm labor [n = 15] and preterm birth [n = 15]), and controls (n = 15). DNA methylation levels at the and in placentas associated with preterm labor did differ significantly (p < 0.05) from controls. Specific alterations in methylation patterns indicative of an unfavourable placental environment are associated with preterm labor per se and not restricted to preterm birth.
本研究旨在确定人类胎盘 DNA 甲基化的改变是否支持疑似早产作为与胎盘健康状况下降相关的病理性损伤。我们使用靶向亚硫酸氢盐测序评估了与早产相关的胎盘（疑似早产后足月分娩[ n = 15]和早产[ n = 15]）和对照组（ n = 15）中七种胎盘病变中差异甲基化的胎盘 DNA 甲基化。与对照组相比，与早产相关的胎盘 和 处的 DNA 甲基化水平差异显著（p < 0.05）。提示胎盘环境不利的甲基化模式的特定改变与早产本身有关，而不仅限于早产。
