呋咱色烯，一种新型色氨酸衍生代谢产物，来自.
Fusarochromene, a novel tryptophan-derived metabolite from .
机构信息
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
出版信息
Org Biomol Chem. 2021 Jan 6;19(1):182-187. doi: 10.1039/d0ob02031a.
Fusarochromene isolated from the plant pathogenic fungus, Fusarium sacchari is closely related to a group of mycotoxins including fusarochromanone previously isolated from various Fusaria spp. Despite their assumed polyketide biogenesis, incorporation studies with 13C-labelled acetate, glycerol and tryptophans show that fusarochromene is unexpectedly derived via oxidative cleavage of the aromatic amino acid tryptophan. A putative biosynthetic gene cluster has been identified.
从植物病原菌真菌——甘蔗镰刀菌中分离得到的呋色胺与包括呋色酮在内的一组真菌毒素密切相关，而呋色酮之前已从各种镰刀菌属真菌中分离得到。尽管它们被认为是通过聚酮生物合成产生的，但用 13C 标记的乙酸盐、甘油和色氨酸进行的掺入研究表明，呋色胺出人意料地是通过芳香族氨基酸色氨酸的氧化裂解产生的。已经鉴定出一个假定的生物合成基因簇。
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