潮霉素 B 诱导次生代谢产物的产生及具有自我抗性基因的 1233A 生物合成基因簇的鉴定。
Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene.
机构信息
Chemical Biology Research Group, RIKEN CSRS, Wako, Saitama, Japan.
Graduate School of Science and Engineering, Saitama University, Sakura, Saitama, Japan.
出版信息
J Antibiot (Tokyo). 2020 Jul;73(7):475-479. doi: 10.1038/s41429-020-0295-4. Epub 2020 Mar 5.
We found that the protein synthesis inhibitor hygromycin B induced the production of secondary metabolites, including lucilactaene, NG-391, fusarubin, 1233A, and 1233B, in the filamentous fungus, Fusarium sp. RK97-94. We identified the biosynthetic gene cluster for 1233A, an HMG-CoA synthase inhibitor. The biosynthetic gene cluster consisted of four genes, one of which was involved in conferring self-resistance to 1233A.
我们发现，蛋白合成抑制剂 Hygromycin B 诱导丝状真菌 Fusarium sp. RK97-94 产生次级代谢产物，包括 lucilactaene、NG-391、fusarubin、1233A 和 1233B。我们鉴定了 HMG-CoA 合酶抑制剂 1233A 的生物合成基因簇。该生物合成基因簇由四个基因组成，其中一个基因参与赋予 1233A 的自我抗性。
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