Department of Occupational Health Engineering, School of Public Health, 48439Tehran University of Medical Sciences, Tehran, Iran.
Department of Occupational Safety and Health Engineering, Health Faculty, 154202Qom University of Medical Sciences, Qom, Iran.
Toxicol Ind Health. 2020 Dec;36(12):960-970. doi: 10.1177/0748233720962238. Epub 2020 Oct 27.
1,3-Butadiene is classified as carcinogenic to humans by inhalation. This study aimed to assess cancer and non-cancer risk following occupational exposure to 1,3-butadiene. This cross-sectional study was conducted in a petrochemical plant producing acrylonitrile butadiene styrene copolymer in Iran. Occupational exposure to 1,3-butadiene was measured according to the National Institute for Occupational Safety and Health 1024 method. Cancer and non-cancer risk assessment were performed according to the United States Environmental Protection Agency method. The average occupational exposure to 1,3-butadiene during work shifts among all participants was 560.82 ± 811.36 µg m. The average lifetime cancer risk (LCR) in the present study was 2.71 × 10; 82.2% of all exposed workers were within the definite carcinogenic risk level. Also, the mean non-cancer risk (hazard quotient (HQ)) among all participants was 10.82 ± 14.76. The highest LCR and HQ were observed in the safety and fire-fighting station workers with values of 7.75 × 10 and 36.57, respectively. The findings revealed that values of carcinogenic and noncarcinogenic risk in the majority of participants were within the definitive and unacceptable risk levels. Therefore, corrective measures are necessary to protect these workers from non-cancer and cancer risks from 1,3-butadiene exposure.
1,3-丁二烯被国际癌症研究机构认定为吸入致癌物质。本研究旨在评估职业接触 1,3-丁二烯后癌症和非癌症风险。本横断面研究在伊朗一家生产丙烯腈丁二烯苯乙烯共聚物的石化厂进行。根据美国国家职业安全与健康研究所 1024 方法测量职业接触 1,3-丁二烯。根据美国环境保护署方法进行癌症和非癌症风险评估。所有参与者在轮班期间的平均职业接触 1,3-丁二烯为 560.82 ± 811.36 µg m。本研究的平均终生癌症风险（LCR）为 2.71 × 10; 82.2%的接触工人处于明确致癌风险水平。此外，所有参与者的平均非癌症风险（危害系数（HQ））为 10.82 ± 14.76。在安全和消防站的工人中观察到最高的 LCR 和 HQ 值，分别为 7.75 × 10 和 36.57。研究结果表明，大多数参与者的致癌和非致癌风险值处于明确和不可接受的风险水平。因此，有必要采取纠正措施，保护这些工人免受 1,3-丁二烯接触引起的非癌症和癌症风险。
