Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.
J Mater Chem B. 2020 Nov 11;8(43):9877-9880. doi: 10.1039/d0tb02120b.
Fluorescent probes in the NIR-II region provide high bioimaging quality. Optimizing the probe structure to achieve NIR-II imaging is ongoing, but remains challenging. Herein, increasing the electron withdrawing ability of the substituent in monochlorinated BODIPY greatly adjusted the emission wavelength from the NIR-I to NIR-II region, giving an efficient design strategy of NIR-II probes.
近红外二区（NIR-II）荧光探针提供了高质量的生物成像。优化探针结构以实现 NIR-II 成像是当前的研究热点，但仍具有挑战性。本文通过增加 BODIPY 类染料中氯原子取代基的吸电子能力，使荧光发射波长从近红外一区（NIR-I）红移至 NIR-II 区，为设计 NIR-II 探针提供了一种有效的策略。
