Research Institute of Traumatology, Orthopedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation, Saratov, Russia.
Bull Exp Biol Med. 2020 Oct;169(6):798-801. doi: 10.1007/s10517-020-04982-8. Epub 2020 Oct 27.
We studied the effect of subbacteriostatic azithromycin concentrations on the formation of microbial biofilms by Pseudomonas aeruginosa strains that caused implant-associated infection of large joints. Azithromycin in subinhibitory for planktonic cells concentrations 0.01-0.02 μg/ml stimulated biofilm formation by both clinical and reference P. aeruginosa strains, while in concentrations of 1 μg/ml and higher completely inhibited the growth of both reference and clinical plankton P. aeruginosa strains, but stimulated biofilm formation. Increasing azithromycin concentration to 10 μg/ml led to inhibition of P. aeruginosa biofilm growth.
我们研究了亚抑菌浓度阿奇霉素对引起大关节植入物相关感染的铜绿假单胞菌菌株形成微生物生物膜的影响。亚抑菌浓度（0.01-0.02μg/ml）的阿奇霉素刺激临床和参考铜绿假单胞菌菌株的生物膜形成，而 1μg/ml 及更高浓度的阿奇霉素完全抑制参考和临床浮游态铜绿假单胞菌菌株的生长，但刺激生物膜形成。将阿奇霉素浓度增加到 10μg/ml 导致铜绿假单胞菌生物膜生长受到抑制。
