《绝命毒师》：缺氧条件下细胞外囊泡引发肿瘤发生反应。
Breaking Bad: Extracellular Vesicles Provoke Tumorigenic Responses Under Oxygen Deprivation.
机构信息
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
出版信息
Dev Cell. 2020 Oct 26;55(2):111-113. doi: 10.1016/j.devcel.2020.09.027.
PMID:33108750
Abstract
Intercellular communication is vital to tumor progression. In this issue of Developmental Cell, Bertolini et al. (2020) describe how small extracellular vesicles released from hypoxic mammary tumor cells facilitate intercellular communication, leading to alterations in mitochondrial dynamics and acquisition of invasive phenotypes in normal epithelial cells.
摘要
细胞间通讯对肿瘤的进展至关重要。在本期《发育细胞》中，Bertolini 等人（2020 年）描述了来自缺氧的乳腺肿瘤细胞释放的小细胞外囊泡如何促进细胞间通讯，导致正常上皮细胞中线粒体动力学的改变和侵袭表型的获得。
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