Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA; Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Cell & Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dev Cell. 2020 Oct 26;55(2):113-115. doi: 10.1016/j.devcel.2020.10.001.
MTORC1 activity is critical for tissue regeneration in multiple organs and contexts. In this issue of Developmental Cell, Miao et al. describe upstream regulators of mTORC1 activity which promote paligenosis, a process where mature cells de-differentiate to acquire stem cell activity in the face of injury.
MTORC1 活性对于多种器官和情况下的组织再生至关重要。在本期《发育细胞》中， Miao 等人描述了促进去分化衰老（一种成熟细胞在面对损伤时去分化获得干细胞活性的过程）的 mTORC1 活性的上游调控因子。
