MTORC1 与干性的重生。

MTORC1 and the Rebirth of Stemness.

机构信息

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA; Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Cell & Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, USA.

出版信息

Dev Cell. 2020 Oct 26;55(2):113-115. doi: 10.1016/j.devcel.2020.10.001.

DOI:10.1016/j.devcel.2020.10.001

PMID:33108751

Abstract

MTORC1 activity is critical for tissue regeneration in multiple organs and contexts. In this issue of Developmental Cell, Miao et al. describe upstream regulators of mTORC1 activity which promote paligenosis, a process where mature cells de-differentiate to acquire stem cell activity in the face of injury.

摘要

MTORC1 活性对于多种器官和情况下的组织再生至关重要。在本期《发育细胞》中， Miao 等人描述了促进去分化衰老（一种成熟细胞在面对损伤时去分化获得干细胞活性的过程）的 mTORC1 活性的上游调控因子。