中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值作为心血管外科手术生物标志物的文献综述
Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio as Biomarkers for Cardiovascular Surgery Procedures: A Literature Review.
作者信息
Serra Raffaele, Ielapi Nicola, Licastro Noemi, Provenzano Michele, Andreucci Michele, Bracale Umberto Marcello, Jiritano Federica, de Franciscis Stefano, Mastroroberto Pasquale, Serraino Giuseppe Filiberto
机构信息
Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology" at the Department of Surgical and Medical Sciences University Magna Graecia of Catanzaro, Viale Europa 88100 Catanzaro, Italy.
Department of Health Sciences, University of Catanzaro, Catanzaro, Italy.
出版信息
Rev Recent Clin Trials. 2021;16(2):173-179. doi: 10.2174/1574887115999201027145406.
BACKGROUND
Neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) have been studied so far as prognostic factors of cardiovascular diseases. Their role interplayed with endothelial inflammation has emerged as optimal predictors for major cardiovascular disease events and prognostic factors for post-procedural outcomes.
METHODS
A review of the current literature was undertaken to investigate the relationship between NLR and PLR with percutaneous, cardiac surgery, and vascular surgery procedures.
RESULTS
Our findings show that perioperative NLR and PLR levels are significantly correlated with patient morbidity and mortality rates.
CONCLUSION
These biomarkers have several attractive characteristics, as they are inexpensive and quickly available, and they can contribute to the early identification of patients at high risk for periprocedural adverse events.
背景
迄今为止，中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）已作为心血管疾病的预后因素进行了研究。它们在内皮炎症中的相互作用已成为主要心血管疾病事件的最佳预测指标和术后结果的预后因素。
方法
对当前文献进行综述，以研究NLR和PLR与经皮手术、心脏手术和血管手术之间的关系。
结果
我们的研究结果表明，围手术期NLR和PLR水平与患者的发病率和死亡率显著相关。
结论
这些生物标志物具有几个吸引人的特点，因为它们价格低廉且可快速获得，并且有助于早期识别围手术期不良事件高危患者。
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