Department of Microbiology and immunology, Kashan University of Medical Sciences, Kashan, Iran.
Department of Microbiology and Applied Microbiology Research Center, Systems biology and poisonings institute, Baqiyatallah University of Medical sciences, Tehran, Iran.
Curr Mol Med. 2021 Apr;21(3):211-220. doi: 10.2174/1566524020999200817113730.
Cancer is one of the most important disorders which is associated with high mortality and high costs of treatment for patients. Despite several efforts, finding, designing and developing, new therapeutic platforms in the treatment of cancer patients are still required. Utilization of microorganisms, particularly bacteria has emerged as new therapeutic approaches in the treatment of various cancers. Increasing data indicated that bacteria could be used in the production of a wide range of anti-cancer agents, including bacteriocins, antibiotics, peptides, enzymes, and toxins. Among these anti-cancer agents, bacteriocins have attractive properties, which make them powerful anti-cancer drugs. Multiple lines evidence indicated that several bacteriocins (i.e., colcins, nisins, pediocins, pyocins, and bovocins) via activation/inhibition different cellular and molecular signaling pathways are able to suppress tumor growth in various stages. Hence, identification and using various bacteriocins could lead to improve and introduce them to clinical practices. Here, we summarized various bacteriocins which could be employed as anti-cancer agents in the treatment of many cancers.
癌症是一种重要的疾病，它与患者的高死亡率和高治疗成本有关。尽管已经做了很多努力，但仍需要寻找、设计和开发新的治疗癌症的平台。利用微生物，特别是细菌，已成为治疗各种癌症的新治疗方法。越来越多的数据表明，细菌可以用于生产多种抗癌药物，包括细菌素、抗生素、肽、酶和毒素。在这些抗癌药物中，细菌素有吸引人的特性，使它们成为强大的抗癌药物。多项研究表明，几种细菌素（如 colcins、nisins、pediocins、pyocins 和 bovocins）通过激活/抑制不同的细胞和分子信号通路，能够抑制肿瘤在各个阶段的生长。因此，鉴定和使用各种细菌素可以提高它们并将其引入临床实践。在这里，我们总结了几种可以作为抗癌药物用于治疗多种癌症的细菌素。
