Ismael Mohamedelfatieh, Huang Mingxin, Zhong Qingping
Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China.
Foods. 2024 Dec 2;13(23):3887. doi: 10.3390/foods13233887.
Bacteriocins produced by lactic acid bacteria (LAB) are promising bioactive peptides. Intriguingly, bacteriocins have health benefits to the host and may be applied safely in the food industry as bio-preservatives or as therapeutic interventions preventing intestinal diseases. In recent years, finding a safe alternative approach to conventional treatments to promote gut health is a scientific hotspot. Therefore, this review aimed to give insight into the promising applications of LAB-bacteriocins in preventing intestinal diseases, such as colonic cancer, infections, multidrug-resistant infection-associated colitis, viral gastroenteritis, inflammatory bowel disease, and obesity disorders. Moreover, we highlighted the recent research on bacteriocins promoting gastrointestinal health. The review also provided insights into the proposed mechanisms, challenges and opportunities, trends and prospects. In addition, a SWOT analysis was conducted on the potential applications. Based on properties, biosafety, and health functions of LAB-bacteriocins, we conclude that the future applications of LAB-bacteriocins are promising in promoting gastrointestinal health. Further in vivo trials are needed to confirm these potential effects of LAB-bacteriocins interventions.
乳酸菌（LAB）产生的细菌素是很有前景的生物活性肽。有趣的是，细菌素对宿主有益健康，并且可以作为生物防腐剂或预防肠道疾病的治疗干预措施安全地应用于食品工业。近年来，寻找一种替代传统治疗方法以促进肠道健康的安全途径是一个科学热点。因此，本综述旨在深入探讨LAB细菌素在预防肠道疾病方面的潜在应用，如结肠癌、感染、多重耐药感染相关结肠炎、病毒性肠胃炎、炎症性肠病和肥胖症。此外，我们强调了近期关于细菌素促进胃肠道健康的研究。该综述还深入探讨了其提出的作用机制、挑战与机遇、趋势和前景。此外，对潜在应用进行了SWOT分析。基于LAB细菌素的特性、生物安全性和健康功能，我们得出结论，LAB细菌素在促进胃肠道健康方面的未来应用前景广阔。需要进一步的体内试验来证实LAB细菌素干预的这些潜在效果。
