Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India.
Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Russian Federation.
Curr Cardiol Rev. 2021;17(3):306-318. doi: 10.2174/1573403X16999200817170619.
Ischemia refers to a reduced supply of oxygen and nutrient to the vital organ of the body. Reperfusion to the ischemic organ is the only way to salvage injury due to ischemia. Paradoxically, reperfusion itself induces the injury, which is more severe than the previous injury referred to as ischemia-reperfusion injury. Ischemia-reperfusion injury is the major cause of mortality in the case of ischemic diseases. The major hurdle for a clinician to treat ischemia is the reperfusion injury, which is encountered in different surgical as well as non-surgical situations. Several therapies, such as anti-platelets, anti-thrombolytic agents have been developed to contain ischemia-reperfusion injury, but with limited success. Over some time, some conditioning techniques such as preconditioning and postconditioning have been used by clinicians to overcome ischemia-reperfusion injury. The present review focuses on the clinical applications of different conditioning techniques in diverse pathological conditions of ischemia-reperfusion injury.
缺血是指身体重要器官的氧气和营养供应减少。再灌注是缺血器官挽救损伤的唯一方法。矛盾的是，再灌注本身会诱导损伤，这种损伤比之前的缺血再灌注损伤更为严重。缺血再灌注损伤是缺血性疾病导致死亡的主要原因。临床医生在治疗缺血时面临的主要障碍是再灌注损伤，这种损伤在不同的手术和非手术情况下都会出现。为了控制缺血再灌注损伤，已经开发了几种治疗方法，如抗血小板、溶栓剂等，但收效甚微。在一段时间内，临床医生使用了一些预处理和后处理等调节技术来克服缺血再灌注损伤。本综述重点介绍了不同调节技术在各种缺血再灌注损伤病理情况下的临床应用。
