Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
BMC Ophthalmol. 2020 Oct 27;20(1):429. doi: 10.1186/s12886-020-01676-7.
Optic disc melanocytoma (ODMC) was a benign pigmented intraocular tumor with the rare potential malignant transformation. This study was designed to evaluate tumor vasculature with optical coherence tomography angiography (OCTA) in ODMC.
Eyes of healthy individuals in a control group and of patients with ODMC were imaged by OCTA systems operating at 840 nm wavelengths and examined. The main outcome measures were OCTA images, qualitative evaluation of optic disc and tumor vasculature, quantitative vascular density (VD) and perfusion density (PD).
One eye of ten normal volunteers and ten patients with ODMC were imaged. Eyes affected by ODMC as compared to the eyes of the control group (all P < 0.05). The healthy optic disc had radially-oriented vessels within the retina on OCTA. Optic disc melanocytoma was characterized by globular, demonstrated tortuous blood vessels, uneven thickness, and relatively disorganized intratumoral vasculature. The VD and PD within ODMC were significantly higher (12.360% ± 4.175, 0.316% ± 0.119%, P < 0.0001) than in normal optic discs (4.160% ± 2.290, 0.102% ± 0.0, 56%, P < 0.0001). No significant differences were established of the VD and PD in each single measurement zone (P > 0.05) between the ODMC and the control eyes. At 840 nm, OCTA could provide sufficient visualization of the tumor vasculature and better penetration through thicker tumors. The full thickness was visualized even in thicker tumors and highly pigmented lesions (> 2 mm). Interpretable OCTA images were obtained in 96% of the participants in whom imaging was attempted.
OCTA may provide a noninvasive, safe, and efficient technique for evaluating a variety of neoplasms including the growth and vascularity in ODMC. OCTA could facilitate the evaluation of the vascular abnormalities of tumors and the effect of melanin on the penetration of the OCTA beam was not significant.
视盘黑色素细胞瘤（ODMC）是一种良性色素性眼内肿瘤，具有罕见的恶性转化潜能。本研究旨在通过光相干断层扫描血管造影（OCTA）评估 ODMC 中的肿瘤血管。
使用 840nm 波长的 OCTA 系统对健康对照组和 ODMC 患者的眼部进行成像和检查。主要观察指标为 OCTA 图像、视盘和肿瘤血管的定性评估、血管密度（VD）和灌注密度（PD）的定量测量。
10 名正常志愿者和 10 名 ODMC 患者的 1 只眼接受了成像。与对照组相比，ODMC 患者的眼部（均 P<0.05）。健康视盘在 OCTA 上显示出视网膜内呈放射状排列的血管。ODMC 表现为球状、迂曲的血管，厚度不均匀，肿瘤内血管相对杂乱。ODMC 中的 VD 和 PD 明显高于正常视盘（12.360%±4.175、0.316%±0.119%，P<0.0001）（4.160%±2.290、0.102%±0.0、56%，P<0.0001）。在 ODMC 和对照组的每一个单一测量区域中，VD 和 PD 均无显著差异（P>0.05）。在 840nm 处，OCTA 可以提供足够的肿瘤血管可视化和更好的穿透更厚的肿瘤。即使在较厚的肿瘤和高色素病变（>2mm）中，也可以可视化全厚度。在尝试成像的 96%的参与者中获得了可解释的 OCTA 图像。
OCTA 可能为评估包括 ODMC 在内的各种肿瘤的生长和血管提供一种非侵入性、安全和有效的技术。OCTA 可以促进对肿瘤血管异常的评估，并且黑色素对 OCTA 光束穿透的影响并不显著。
