Department of Ophthalmology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510000, People's Republic of China.
Department of General Intensive Care Unit, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Graefes Arch Clin Exp Ophthalmol. 2020 Feb;258(2):437-444. doi: 10.1007/s00417-019-04466-0. Epub 2019 Nov 15.
This study aims to describe the variation and characteristics of vessel density (VD) of the macula and optic disc in the normal eyes of children.
This was a retrospective study where subjects aged 5-18 years with normal eyes were enrolled. The macula and optic disc were scanned by optical coherence tomography angiography (OCTA). The influences of age, gender, and axial length (AL) on VD were analyzed.
A total of 71 normal eyes from 71 subjects were enrolled. For the macula, the mean VD of fovea, parafovea, and perifovea at superficial retina and deep retina were 20.1%, 50.2%, 49.4%, 36.1%, 53.9%, and 48.1%, respectively. The mean foveal avascular zone (FAZ) was 0.277 mm. For optic disc, the mean VD of radial peripapillary capillary (RPC) and inside-disc areas were 51.8% and 51.7%, respectively. Significant differences were found between the superior-hemi and inferior-hemi VD of the superficial retinal parafovea, deep retinal perifovea, and perifovea. The fovea VD of the superficial and deep retina and FAZ areas were different between genders. The inside-disc VD was positively correlated with AL, while other VDs had no significant correlation with age and AL.
The parafovea VD of the superficial retina, parafovea, and perifovea of the deep retina had superior-hemi VD; boys had a higher fovea VD and smaller FAZ area than those of girls, the macular VD and peripapillary RPC density were steady for 5-18 year-olds. This study provided useful information for furthering the understanding of the development mode of vessel in children and the OCTA clinical applications in children.
本研究旨在描述儿童正常眼黄斑和视盘血管密度（VD）的变化和特征。
这是一项回顾性研究，纳入了年龄在 5-18 岁之间的正常眼受试者。使用光学相干断层扫描血管造影（OCTA）对黄斑和视盘进行扫描。分析年龄、性别和眼轴（AL）对视盘 VD 的影响。
共纳入 71 名受试者的 71 只正常眼。对于黄斑，浅层视网膜和深层视网膜的中心凹、旁中心凹和中心凹周围的平均 VD 分别为 20.1%、50.2%、49.4%、36.1%、53.9%和 48.1%，平均中心凹无血管区（FAZ）为 0.277mm。对于视盘，放射状视盘周围毛细血管（RPC）和视盘内区域的平均 VD 分别为 51.8%和 51.7%。浅层视网膜旁中心凹、深层视网膜中心凹周围和中心凹周围的上半和下半 VD 存在显著差异。男性浅层和深层视网膜中心凹 VD 和 FAZ 面积均大于女性。视盘内 VD 与 AL 呈正相关，而其他 VD 与年龄和 AL 无显著相关性。
浅层视网膜旁中心凹、深层视网膜旁中心凹和中心凹周围的 VD 具有上半优势；男孩的中心凹 VD 高于女孩，FAZ 面积小于女孩，5-18 岁儿童黄斑 VD 和视盘周围 RPC 密度稳定。本研究为进一步了解儿童血管发育模式以及 OCTA 在儿童中的临床应用提供了有用信息。
