Sieratzki J, Thung S N, Gerber M A, Ferrone S, Schaffner F
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029.
Arch Pathol Lab Med. 1987 Nov;111(11):1045-9.
Human leukocyte antigen (HLA) class I molecules are normally detected on most nucleated cells, but not on hepatocytes, while the expression of HLA class II antigens is mainly restricted to certain cell types of the immune system. This normal distribution pattern may be altered in human liver in a variety of disorders, particularly in infectious and immune diseases. In view of multiple infections and severe immune alterations in acquired immunodeficiency syndrome (AIDS), we studied the expression of HLA class I and class II antigens in liver obtained at autopsy from ten patients with AIDS and eight control patients, using a panel of monoclonal antibodies and the indirect immunofluorescence method. In spite of viral bacterial, and fungal infections, HLA class I antigens were detected on hepatocytes in only two patients with AIDS. Human leukocyte antigen class II antigens were found unexpectedly on bile duct epithelium in five of ten patients with AIDS and in one of eight control patients. The aberrant HLA class II antigen expression on bile ducts does not appear to be linked to bile duct damage or infection with cytomegalovirus or other agents, but may be related to immune alterations in patients with AIDS.
人类白细胞抗原（HLA）I类分子通常在大多数有核细胞上可检测到，但在肝细胞上则检测不到，而HLA II类抗原的表达主要局限于免疫系统的某些细胞类型。在人类肝脏中，这种正常的分布模式在多种疾病中可能会发生改变，尤其是在感染性疾病和免疫性疾病中。鉴于获得性免疫缺陷综合征（艾滋病）存在多种感染及严重的免疫改变，我们使用一组单克隆抗体和间接免疫荧光法，研究了10例艾滋病患者及8例对照患者尸检肝脏中HLA I类和II类抗原的表达情况。尽管存在病毒、细菌和真菌感染，但仅在2例艾滋病患者的肝细胞上检测到了HLA I类抗原。意外的是，在10例艾滋病患者中有5例以及8例对照患者中有1例的胆管上皮细胞上发现了HLA II类抗原。胆管上异常的HLA II类抗原表达似乎与胆管损伤或巨细胞病毒或其他病原体感染无关，但可能与艾滋病患者的免疫改变有关。
