Chisati Enock M, Constantinou Demitri, Lampiao Fanuel
Department of Physiotherapy, College of Medicine, University of Malawi, Blantyre, Malawi.
Consortium for Advanced Research Training in Africa, Nairobi, Kenya.
BMC Sports Sci Med Rehabil. 2020 Oct 23;12:67. doi: 10.1186/s13102-020-00216-6. eCollection 2020.
Anti-retroviral therapy (ART) is associated with low bone mineral density (BMD) among people living with HIV (PLWHIV). Although physical activity is recommended for improving bone health in patients with reduced BMD, data on effects of strength exercises on low BMD among PLWHIV is scarce. This study therefore aimed to determine the effects of a 12 weeks maximal strength training (MST) on BMD among PLWHIV in Blantyre, Malawi.
Twenty-six PLWHIV with reduced BMD were randomised into a training group (TG, = 15) and control group (CG, = 11). The TG underwent 12 weeks of MST consisting of 4 sets of 3 to 5 repetitions at 85-90% of one repetition maximum (1RM) 3 times per week. The CG was advised to maintain their usual lifestyle. Measurements of BMD using dual-energy X-ray absorptiometry, 1RM using a squat machine, heart rate using a heart rate monitor, weight, height and body mass index were obtained before and after the intervention in the TG and CG. Descriptive statistics and student's t - tests were used to analyse data.
The study was conducted for 12 weeks. Data of 24 participants [14 (TG) and 10 (CG)] were analysed. At base line, there were no significant differences in age ( = 0.34), height ( = 0.91), weight ( = 0.43) and body mass index ( = 0.34) between participants in the TG and the CG. After the intervention, there were significant improvements in lumbar BMD ( < 0.001) and resting heart rate ( = 0.03) in the TG compared to the CG. There were significant improvements in muscle strength (1 RM) in both the TG ( < 0.001) and the CG ( = 0.01).
MST improves lumbar BMD and strength in PLWHIV receiving ART in Blantyre, Malawi. MST with a shorter exercise duration of 12 weeks seem to have the potential in treating reduced BMD in PLWHIV.
PACTR201712002889203. Registered with the Pan African Clinical Trial Registry on 22nd December, 2017 at www. pactr.org.
抗逆转录病毒疗法（ART）与人类免疫缺陷病毒感染者（PLWHIV）的低骨矿物质密度（BMD）有关。尽管建议进行体育活动以改善骨密度降低患者的骨骼健康，但关于力量训练对PLWHIV低骨密度影响的数据却很少。因此，本研究旨在确定为期12周的最大力量训练（MST）对马拉维布兰太尔PLWHIV骨密度的影响。
26名骨密度降低的PLWHIV被随机分为训练组（TG，n = 15）和对照组（CG，n = 11）。TG组接受为期12周的MST，包括每周3次，每次4组，每组3至5次重复，强度为一次重复最大值（1RM）的85-90%。建议CG组维持其平常的生活方式。在TG组和CG组干预前后，使用双能X线吸收法测量骨密度，使用深蹲机测量1RM，使用心率监测仪测量心率，测量体重、身高和体重指数。使用描述性统计和学生t检验分析数据。
该研究进行了12周。分析了24名参与者的数据[14名（TG组）和10名（CG组）]。在基线时，TG组和CG组参与者在年龄（P = 0.34）、身高（P = 0.91）、体重（P = 0.43）和体重指数（P = 0.34）方面没有显著差异。干预后，与CG组相比，TG组的腰椎骨密度（P < 0.001）和静息心率（P = 0.03）有显著改善。TG组（P < 0.001）和CG组（P = 0.01）的肌肉力量（1RM）均有显著改善。
在马拉维布兰太尔接受ART治疗的PLWHIV中，MST可改善腰椎骨密度和力量。为期12周、运动时间较短的MST似乎有治疗PLWHIV骨密度降低的潜力。
PACTR201712002889203。于2017年12月22日在www.pactr.org上注册于泛非临床试验注册中心。
