Yousuf Muhammad, Reza Sara, Zafar Saleha, Noor Shehnaz, Sarfraz Lubna, Iqbal Muhammad, Laique Talha
Pathology, Quaid-e-Azam Medical College, Bahawalpur, PAK.
Cardiology, Cardiac Centre, Bahawalpur, PAK.
Cureus. 2020 Sep 22;12(9):e10584. doi: 10.7759/cureus.10584.
Background and objective Acute pulmonary embolism (APE) is a serious cardiovascular emergency, mainly secondary to deep vein thrombosis (DVT), which causes death. The goal of the current study was to determine the levels of different serum markers in combination among patients with and without acute pulmonary embolism in order to use them as a diagnostic tool. Methodology A sample of 96 patients was kept with a 90% power of study and a 5% level of significance in the current study. It was carried from January to June 2020 in the Department of Medicine, Bahawal Victoria Hospital, Bahawalpur, after the hospital's Ethical Committee approval. Written informed consent was taken. Serum levels of C-reactive protein (CRP), D-dimer, fibrinogen, and Troponin-I between both groups were done once enrolled. SPSS software, version 25 (IBM Corp. Armonk, NY) was used to analyze the collected data. Results Patients with acute pulmonary embolism had a mean age of 50.4 ± 10.4 years. All serum markers were significantly raised in patients suffering from acute pulmonary embolism with a p-value of <0.05. Conclusion We concluded that all these serum markers can be used together as a tool in making the correct diagnosis of acute pulmonary embolism in our setup.
背景与目的 急性肺栓塞（APE）是一种严重的心血管急症，主要继发于导致死亡的深静脉血栓形成（DVT）。本研究的目的是确定急性肺栓塞患者与非急性肺栓塞患者不同血清标志物的联合水平，以便将其用作诊断工具。方法 在本研究中，以90%的检验效能和5%的显著性水平保留了96例患者的样本。该研究于2020年1月至6月在巴哈瓦尔布尔巴哈瓦尔维多利亚医院内科进行，经医院伦理委员会批准。获取了书面知情同意书。两组患者入组后均检测了血清C反应蛋白（CRP）、D-二聚体、纤维蛋白原和肌钙蛋白I水平。使用SPSS 25版软件（IBM公司，纽约州阿蒙克）分析收集的数据。结果 急性肺栓塞患者的平均年龄为50.4±10.4岁。急性肺栓塞患者的所有血清标志物均显著升高，p值<0.05。结论 我们得出结论，在我们的研究中，所有这些血清标志物可一起用作正确诊断急性肺栓塞的工具。
