一种具有位置偏向性纤维断裂特征的淀粉样蛋白动力学建模的简单方法。
A simple method for modeling amyloid kinetics featuring position biased fiber breakage.
作者信息
Hall Damien
机构信息
Laboratory of Biochemistry and Genetics, NIDDK, NIH, Bethesda, MD 20892-0830, USA.
Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.
出版信息
Biophys Physicobiol. 2020 Mar 20;17:30-35. doi: 10.2142/biophysico.BSJ-2020003. eCollection 2020.
Abstract
A mathematical model of amyloid fiber formation is described that is able to simply specify different rates of fiber breakage at internal versus end regions. This Note presents the derivation of the relevant equations and provides results showing the dramatic effects of position biased fiber breakage on the kinetics of amyloid growth.
摘要
描述了一种淀粉样纤维形成的数学模型，该模型能够简单地指定内部区域与末端区域不同的纤维断裂速率。本注释给出了相关方程的推导，并提供了结果，表明位置偏向的纤维断裂对淀粉样蛋白生长动力学具有显著影响。
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