Dehghani Alireza, Ghanbari Heshmatollah, Akhlaghi Mohammadreza, Kianersi Farzan, Alemzadeh-Ansari Mohammad-Hasan
Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.
Taiwan J Ophthalmol. 2019 Feb 18;10(3):184-188. doi: 10.4103/tjo.tjo_67_18. eCollection 2020 Jul-Sep.
The purpose of this study was to examine macular and peripapillary choroidal thickness (CT) in patients with acute unilateral retrobulbar optic neuritis.
In this cross-sectional study, 19 patients with acute unilateral retrobulbar optic neuritis were examined. A control group was matched with patients for sex and age. Enhanced depth imaging optical coherence tomography in macula and peripapillary areas in both eyes was performed for evaluation of CT. The CT was measured in subfoveal and other six points of macula and four points of peripapillary areas with a 3.4-mm scan circle centered on the optic nerve head.
The mean subfoveal CT was 384.7 ± 101.6 μm, 380.5 ± 109 μm, and 401.2 ± 84.6 μm for affected eye, unaffected fellow eye, and healthy control, respectively. All measurements of macular CT were thinner in the patient group compared with healthy controls. Global peripapillary CT in affected eyes, unaffected fellow eyes, and healthy controls were 202 ± 43.3, 195.1 ± 42.9, and 234 ± 71.2, respectively. The difference between the three groups was statistically significant in the nasal point of peripapillary area ( = 0.023). No correlation was seen between CT and initial visual acuity or duration from symptom onset to medical survey in acute phase of retrobulbar optic neuritis.
Patients with acute retrobulbar optic neuritis showed no significantly thinner macular and peripapillary CT in both eyes compared with healthy controls.
本研究旨在检测急性单侧球后视神经炎患者的黄斑和视乳头周围脉络膜厚度（CT）。
在这项横断面研究中，对19例急性单侧球后视神经炎患者进行了检查。设立了一个在性别和年龄上与患者相匹配的对照组。对双眼的黄斑和视乳头周围区域进行增强深度成像光学相干断层扫描，以评估CT。以视神经乳头为中心，用3.4毫米的扫描圈在黄斑中心凹下及其他六个点和视乳头周围区域的四个点测量CT。
患眼、对侧未患眼和健康对照的平均黄斑中心凹下CT分别为384.7±101.6μm、380.5±109μm和401.2±84.6μm。与健康对照相比，患者组黄斑CT的所有测量值均较薄。患眼、对侧未患眼和健康对照的视乳头周围整体CT分别为202±43.3、195.1±42.9和234±71.2。视乳头周围区域鼻侧点的三组间差异具有统计学意义（=0.023）。在球后视神经炎急性期，CT与初始视力或从症状发作到医学检查的持续时间之间未见相关性。
与健康对照相比，急性球后视神经炎患者双眼的黄斑和视乳头周围CT未见明显变薄。
