Blumer S O, Kaufman L
Mycopathologia. 1977 Jul 29;61(1):55-60. doi: 10.1007/BF00440759.
Immunoglobulin G (IgG), immunoglobulin M (IgM) and immunoglobulin A (IgA) levels were determined by radial immunodiffusion techniques in sera from 11 patients with cryptococcosis. Most specimens showed increased levels of IgM. Studies with fluorescein-labeled monospecific antihuman IgG and IgM, however, indicated that IgG was the immunoglobulin reactive in the indirect fluorescent antibody (IFA) test. In addition, cross-reacting sera from mycotic infections other than cryptococcosis were also shown to contain IFA antibodies of the IgG class. Sera treated with 2-mercaptoethanol continued to react in both the IFA test and the tube agglutination test. No correlation could be established between IgG AND IgM concentrations and serological reactivity in the sera evaluated in this study.
采用放射免疫扩散技术测定了11例隐球菌病患者血清中的免疫球蛋白G（IgG）、免疫球蛋白M（IgM）和免疫球蛋白A（IgA）水平。大多数标本显示IgM水平升高。然而，用荧光素标记的单特异性抗人IgG和IgM进行的研究表明，IgG是间接荧光抗体（IFA）试验中具有反应性的免疫球蛋白。此外，来自隐球菌病以外的真菌感染的交叉反应血清也显示含有IgG类的IFA抗体。用2-巯基乙醇处理的血清在IFA试验和试管凝集试验中均继续发生反应。在本研究评估的血清中，IgG和IgM浓度与血清学反应性之间未发现相关性。
