Dromer F, Aucouturier P, Clauvel J P, Saimot G, Yeni P
Laboratoire des Infections Expérimentales, Faculté Xavier Bichat, Paris, France.
Scand J Infect Dis. 1988;20(3):283-5. doi: 10.3109/00365548809032452.
Anti-Cryptococcus neoformans capsular polysaccharide (CPS) antibodies were measured by ELISA in patients with AIDS related complex or AIDS without a known history of cryptococcosis and in heterosexual healthy controls. Total and IgG anti-CPS antibody activity was rarely detected in patients, with mean levels lower than in controls, whereas IgM antibody activity was similar in the 3 groups. Since both humoral and cellular immunity appear to be of great importance during cryptococcosis, the inability of AIDS patients to synthetize specific IgG antibodies could impair an alternative host defence mechanism to cellular immunity.
采用酶联免疫吸附测定法（ELISA）检测了艾滋病相关综合征患者或无隐球菌病已知病史的艾滋病患者以及异性健康对照者体内的抗新型隐球菌荚膜多糖（CPS）抗体。在患者中很少检测到总抗CPS抗体活性和IgG抗CPS抗体活性，其平均水平低于对照组，而IgM抗体活性在三组中相似。由于在隐球菌病期间体液免疫和细胞免疫似乎都非常重要，艾滋病患者无法合成特异性IgG抗体可能会损害细胞免疫的一种替代宿主防御机制。
