Laboratory for Biomimetic Chemistry, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia.
J Org Chem. 2020 Nov 6;85(21):14253-14261. doi: 10.1021/acs.joc.0c02225. Epub 2020 Oct 28.
A formal Betti reaction between variously substituted phenols and benzophenone-derived imines to afford α-triphenylmethylamines is reported. The key to the success of this transformation is the generation of the reactive benzophenone iminium species under organocatalytic conditions. Different phenols reacted smoothly, enabling the synthesis of an array of α-triphenylmethylamines, which are highly valued structural motifs in bioactive molecules and chemical sensors.
本文报道了各种取代酚与二苯甲酮衍生亚胺之间的正式Betti 反应，生成α-三苯甲基胺。这种转化成功的关键是在有机催化条件下生成反应性的二苯甲酮亚胺物种。不同的酚类化合物反应顺利，从而能够合成一系列的α-三苯甲基胺，这些都是生物活性分子和化学传感器中非常有价值的结构基序。
