3,5-二芳基取代的5-羟基-1,5-二氢-2-吡咯-2-酮的制备：3-氰基酮的碱辅助环化反应

Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2-pyrrol-2-ones base-assisted cyclization of 3-cyanoketones.

作者信息

Aksenov Nicolai A, Aksenov Dmitrii A, Kurenkov Igor A, Aksenov Alexander V, Skomorokhov Anton A, Prityko Lidiya A, Rubin Michael

机构信息

Department of Chemistry, North Caucasus Federal University 1a Pushkin St. Stavropol 355009 Russian Federation

Department of Chemistry, University of Kansas 1567 Irving Hill Rd Lawrence KS 66045-7582 USA

出版信息

RSC Adv. 2021 Apr 30;11(27):16236-16245. doi: 10.1039/d1ra02279b.

A convenient preparative method is developed allowing for expeditious assembly of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2-pyrrol-2-ones from routinely available inexpensive synthetic precursors. These compounds could not be prepared the previously known protocols, as 2-aminofuran derivatives were produced instead.