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3,5-二芳基取代的5-羟基-1,5-二氢-2-吡咯-2-酮的制备：3-氰基酮的碱辅助环化反应

Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2-pyrrol-2-ones base-assisted cyclization of 3-cyanoketones.

作者信息

Aksenov Nicolai A, Aksenov Dmitrii A, Kurenkov Igor A, Aksenov Alexander V, Skomorokhov Anton A, Prityko Lidiya A, Rubin Michael

机构信息

Department of Chemistry, North Caucasus Federal University 1a Pushkin St. Stavropol 355009 Russian Federation

Department of Chemistry, University of Kansas 1567 Irving Hill Rd Lawrence KS 66045-7582 USA

出版信息

RSC Adv. 2021 Apr 30;11(27):16236-16245. doi: 10.1039/d1ra02279b.

DOI:10.1039/d1ra02279b
PMID:35479147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9032200/
Abstract

A convenient preparative method is developed allowing for expeditious assembly of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2-pyrrol-2-ones from routinely available inexpensive synthetic precursors. These compounds could not be prepared the previously known protocols, as 2-aminofuran derivatives were produced instead.

摘要

开发了一种简便的制备方法，可从常规可得的廉价合成前体快速组装3,5 - 二芳基取代的5 - 羟基 - 1,5 - 二氢 - 2 - 吡咯 - 2 - 酮。按照先前已知的方案无法制备这些化合物，因为会生成2 - 氨基呋喃衍生物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185a/9032200/6112a1cdbd53/d1ra02279b-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185a/9032200/e2ea5afffdc9/d1ra02279b-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185a/9032200/ea2afaf8e688/d1ra02279b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185a/9032200/5b62aede1341/d1ra02279b-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185a/9032200/1ba2f0be02f9/d1ra02279b-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185a/9032200/10649b13cc78/d1ra02279b-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185a/9032200/6112a1cdbd53/d1ra02279b-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185a/9032200/e2ea5afffdc9/d1ra02279b-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185a/9032200/ea2afaf8e688/d1ra02279b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185a/9032200/5b62aede1341/d1ra02279b-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185a/9032200/1ba2f0be02f9/d1ra02279b-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185a/9032200/10649b13cc78/d1ra02279b-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185a/9032200/6112a1cdbd53/d1ra02279b-f3.jpg

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