Obesity Centre CGG, Department of Internal Medicine.
Division of Endocrinology, Department of Internal Medicine.
Eur J Endocrinol. 2020 Dec;183(6):669-676. doi: 10.1530/EJE-20-0077.
Obesity and cardiometabolic diseases are associated with higher long-term glucocorticoid levels, measured as scalp hair cortisol (HairF) and cortisone (HairE). Cardiometabolic diseases have also been associated with copeptin, a stable surrogate marker for the arginine-vasopressin (AVP) system. Since AVP is, together with corticotropin-releasing hormone (CRH) an important regulator of the hypothalamic-pituitary adrenal axis (HPA axis), we hypothesize that AVP contributes to chronic hypercortisolism in obesity.
To investigate whether copeptin levels are associated with Higher HairF and HairE levels in obesity.
A cross-sectional study in 51 adults with obesity (BMI ≥30 kg/m2).
Associations and interactions between copeptin, HairF, HairE, and cardiometabolic parameters were cross-sectionally analyzed.
Copeptin was strongly associated with BMI and waist circumference (WC) (rho = 0.364 and 0.530, P = 0.008 and <0.001, respectively), also after correction for confounders. There were no associations between copeptin and HairF or HairE on a continuous or dichotomized scale, despite correction for confounders.
In patients with obesity, AVP seems not a major contributor to the frequently observed high cortisol levels. Other factors which stimulate the HPA axis or affect cortisol synthesis or breakdown may be more important than the influence of AVP on long-term glucocorticoid levels in obesity.
肥胖和心血管代谢疾病与长期皮质醇水平升高有关，可通过头皮毛发皮质醇（HairF）和皮质酮（HairE）来测量。心血管代谢疾病也与 copeptin 有关，copeptin 是精氨酸加压素（AVP）系统的稳定替代标志物。由于 AVP 与促肾上腺皮质激素释放激素（CRH）一起是下丘脑-垂体-肾上腺轴（HPA 轴）的重要调节因子，我们假设 AVP 导致肥胖中的慢性高皮质醇血症。
研究 copeptin 水平是否与肥胖中的高 HairF 和 HairE 水平相关。
对 51 名肥胖成年人（BMI≥30kg/m2）进行的横断面研究。
分析 copeptin 与 HairF、HairE 和心血管代谢参数之间的关联和相互作用。
cOpeptin 与 BMI 和腰围（WC）呈强相关（rho=0.364 和 0.530，P=0.008 和 <0.001），即使在调整混杂因素后也是如此。尽管调整了混杂因素，但 copeptin 与 HairF 或 HairE 之间在连续或二分尺度上均无关联。
在肥胖患者中，AVP 似乎不是导致经常观察到的高皮质醇水平的主要因素。刺激 HPA 轴或影响皮质醇合成或分解的其他因素可能比 AVP 对肥胖中长期糖皮质激素水平的影响更为重要。
